Abstract Library

#4256 Epigenetic prediction of aging and metabolic traits provides insight into tumor biology in multi-focal ileal neuroendocrine tumors

Introduction: Approximately half of small intestinal neuroendocrine tumors (siNETs) are multifocal, and recent investigations into the genetic architecture of these tumors have found that they are not clonal. Due to the low mutational rate and slow growing nature of these small tumors, the ‘timing’ of the development of individual tumors has not been possible.

Conference:

Presenting Author:

Authors: Webster A, Makinen N, Ecker S, Beck S, Nakakura E,

Keywords: DNA methylation, Epigenetics, Multifocal Ileal Neuroendocrine Tumor, Multifocal Small Instestinal NET, Metabolic Traits,

#4166 Characterising the tumor microenvironment of multifocal small intestinal NETs

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) are thought to arise from enterochromaffin cells of the gut, often with multiple synchronous primary tumors. Recently, we showed that synchronous primary tumors from the same SI-NET patient display distinct somatic mutational profiles, suggesting that these tumors originate independently, despite few clear driver mutations. Thus, new mechanistic insights into multifocal SI-NETs are urgently needed.

Conference:

Presenting Author:

Authors: Mäkinen N, Lee I, Dohlman A, Gao T, Zhang Z,

Keywords: small intestinal NET, tumor microenvironment, tumor microbiome,

#4133 Clinical impact and prognosis of patients with Si-NET and bone metastases – Do they matter?

Introduction: The prevalence of bone metastases (BM) in small intestinal neuroendocrine tumors (Si-NET) ranges from 5 to 23 %.

Conference:

Presenting Author: Wedin M

Authors: Wedin M, Daskalakis K, Tiensuu Janson E, Sundin A, Wallin G,

Keywords: bone metastases, si-net, Neuroendocrine Neoplasm,

#4129 Validation of a radiomics model to predict symptoms complications from small intestinal NET mesenteric metastases – Preliminary report

Introduction: The development of mesenteric metastases and associated mesenteric fibrosis in small intestinal neuroendocrine tumors (SI-NET) can cause significant complications and have implications in patients’ survival. CT is suboptimal for accurate assessment of the degree of fibrosis and prediction of complications. A better model is needed, therefore, in order to select patients who may benefit from a prophylactic surgical approach in the mesentery. Recently the promising role of a radiomics model was shown as a predictive tool for development of complications of mesenteric metastases/fibrosis in 68 patients.

Conference:

Presenting Author:

Authors: von Stempel C, Blazevic A, Starmans M, d' Afflitto M, de Herder W,

Keywords: small intestinal neuroendocrine tumor, mesenteric fibrosis, complications, radiomics,

#4071 Hospital record data on the clinical presentation and diagnostic investigations of small intestinal neuroendocrine tumors (SI-NETs)

Introduction: The diagnosis of small intestinal neuroendocrine tumors(SI-NETs) is often delayed due to non-specific symptoms, difficulty imaging, and lack of awareness.

Conference:

Presenting Author: Gould H

Authors: Gould H, Kapish A, Karategos T, Abbas S, Olive S,

Keywords: small intestinal neuroendocrine tumor, investigation, Colonoscopy, CT, presentation, symptoms, Diagnosis,