Abstract Library

#4379 Fully automated segmentation and lymph node metastasis prediction of non-functional pancreatic neuroendocrine tumours using deep learning

Introduction: Lymph node status is an important factor for the patients with NF-PanNETs with respect to surgical methods, prognosis, and recurrence. Our model serves as a non-invasive tool that supports clinical decision-making for precision surgical treatment in patients with NF-PanNETs.

Conference:

Presenting Author: Tang W

Authors: Tang W, Chen J,

Keywords: Non-functional pancreatic neuroendocrine tumour, deep learning, fully automated segmentation, imaging Informatics,

#3586 Grading diagnostic accuracy of EUS Tissue Acquisition in pancreatic neuroendocrine tumors: A systematic review and meta-analysis

Introduction: Pancreatic neuroendocrine neoplasms (PanNENs), are a form of neoplasms arising from cells of the endocrine and nervous systems. Grading (G) is one of the most important decisional factor for therapy as is associated with prognosis, overall survival and disease free survival decrease. Endoscopic ultrasound fine needle-aspiration/biopsy (EUS-FNA/B) is the gold standard for diagnosing PanNENs and Ki67 evaluation, but data regarding accuracy and concordance with post-surgical histological examination are scanty and heterogeneous.

Conference:

Presenting Author:

Authors: Tacelli M, Bina N, Crinò S, Facciorusso A, Barresi L,

Keywords: endoscopic ultrasound, net, ki67, who, misclassification,

#3575 Claudin 18 immunohistochemistry for determining site of origin of metastatic neuroendocrine tumor

Introduction: Claudin 18 isoform 2 (CLDN18.2) is selectively expressed in normal and neoplastic gastric tissue and some pancreatic neoplasia. Anti-CLDN18.2 is an investigational therapy in gastric and pancreatic adenocarcinoma and a sensitive and specific immunohistochemical marker in these cancers.

Conference:

Presenting Author: Smith B

Authors: Smith B, Rice K, Setthavongsack N, Woltjer R, Wong M,

Keywords: neuroendocrine, immunohistochemistry, claudin 18, CLDN18, gastric,

#2951 Analysis of Discordance between Biopsy Grade and Surgical Pathology Grade in Resected PanNEN Patients

Introduction: In PanNEN cases, treatment strategies are decided by tumor localization, volume and grade. In unresectable or metastatic cases, tumor grade is determined by biopsy specimen obtained from EUS-FNA and diagnostic accuracy of biopsy according to WHO classification 2017 is important for decision making of treatment.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Nakano K, Masui T, Yogo A, Uchida Y, Nagai K,

Keywords: PanNEN, WHO classification 2017, EUS-FNA, Ki-67, biopsy, surgical pathology, discordance,

#50 Clinical-morphology correlation in diagnostics and evaluating surgery results of pancreatic insulinoma and nesidiobastosis

Introduction: Organic hyperinsulinism syndrome (OHS) is revealed in 85% cases of pancreas insulinoma. Nesidioblastosis (NB) induces OHS in 15% of the cases. Surgical cure provides all symptoms of insulinoma disappearing, while cytoreductive operation results in considerable improvement of life quality. There is no intraoperative opportunity to reveal insulinoma grade, even if an urgent biopsy is performed. Thus, it is essential to determine the cause of OHS and to apply the surgical cure method during the preoperational period, thereby improving the long-term prognosis.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Askenderova E, Egorov A, Gurevich L, Borodatova E,

Keywords: organic hyperinsulinism syndrome, insulinoma, nesidioblastosis,,