Abstract Library

#3468 Novel morphological tools in predicting pancreatic neuroendocrine tumors (Pan-Net) clinical outcome

Introduction: Pancreatic Neuroendocrine Tumor (Pan-NET) clinical outcome shows a high variability among patients within the same World Health Organization (WHO) category. To date, there is a lack of markers to predict recurrence after resection, which makes it difficult to identify patients with higher risk of progression.

Conference:

Presenting Author:

Authors: Lagano V, Sabella G, Cattaneo L, Grillo F, Mangogna A,

Keywords: Pancreas, parenchymal infiltration, tumor deposits,

#2289 Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Receptor Expression in Patients with Neuroendocrine Neoplasia

Introduction: Targeting the death receptor pathway of apoptosis represents a promising approach for the development of novel cancer therapeutics. TNF-related TRAIL induces apoptosis upon binding to TRAIL receptors 1 and 2 (TRAIL-R1/DR4 and TRAIL-R2/DR5). TRAIL-R3 (DcR1) and TRAIL-R4 (DcR2) have been reported to block TRAIL-mediated apoptosis upon overexpression. Specially agonists for the apoptosis-inducing TRAIL-R1 and TRAIL-R2 are currently tested in clinical trials.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Sättele R, Jann H, Fischer C, Pape U, Schefold J,

Keywords: TRAIL, apoptosis, NENs,

#2197 Tumor Necrosis of Primary Malignancy Affects Survival and Outcome in Patients with Liver Metastases from Neuroendocrine Tumors

Introduction: Reliable biomarkers represent a crucial unmet need in the management of neuroendocrine tumors. Tumor necrosis has been suggested to have a prognostic value in selected solid tumors but is not included in established WHO NET Grading Systems. However, little is known regarding the influence of tumor necrosis on tumor progression and prognosis in patients with liver metastasis from neuroendocrine tumors.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Atanasov G

Authors: Atanasov G, Tsvetkova I, Strücker B, Andreou A, Bahra M,

Keywords: net, liver metastases, biomarker, tumor necrosis,

#1888 Selective Transarterial Embolization of Gastro-Entero Pancreatic (GEP) Neuroendocrine Tumors (NET) with Advanced Locoregional Disease and/or Liver Metastases

Introduction: Selective transarterial embolization(TAE) and chemoembolization(TACE),are alternative options to systemic therapies in patients with GEP-NET G1/G2 with advanced locoregional disease and/or unresectable liver metastases

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Blanco C, Crespo E, Gamo M, Villalobos L, Escribano P,

Keywords: TACE, TAE, GEP-NET,