Abstract Library

#3925 Telomerase-independence function of Dyskerin is therapeutic vulnerability in TP53 mutant pancreatic neuroendocrine tumors

Introduction: Pancreatic neuroendocrine tumors (PanNETs) utilize the recombination-mediated alternative lengthening of telomeres (ALT) mechanism, rather than telomerase, for the maintenance of telomeres.

Conference:

Presenting Author: Ji S

Authors: Ji S, Lou X, Zhou C, Xu X, Chen J,

Keywords: pancreatic neuroendocrine tumor, tp53 mutant, dyskerin, temozolomide,

#3608 Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in non-functional pancreatic neuroendocrine tumors

Introduction: Death domain-associated protein (DAXX) and/or α-thalassemia/mental retardation X-linked (ATRX) chromatin remodelling genes mutations and alternative lengthening of telomeres (ALT) activation are associated with more aggressive behaviour of non-functional pancreatic neuroendocrine tumors (NF-pNETs).

Conference:

Presenting Author:

Authors: Mastrosimini M, Manfrin E, Remo A, de Bellis M, Pedron S,

Keywords: pancreatic tumor, ALT, FISH, immunohistochemistry,

#2986 Characterization of 142 Human Pancreatic Neuroendocrine Tumors: ATRX and DAXX Correlation with Clinical-Pathological Data

Introduction: Pancreatic neuroendocrine tumors (PNETs) are rare and heterogeneous neoplasms with a 10-year survival rate less than 30%. Up to 43% of them are driven by inactivating mutations in ATRX or DAXX. These are important players at chromatin remodeling, that when mutated prone cancer cells to initiate the alternative lengthening of telomeres (ALT). ALT phenotype correlates with in situ loss of expression of the proteins ATRX or DAXX and can be corroborated by telomere-FISH.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Gaspar T, Pinheiro J, Canberk S, İnce �, Tokat F,

Keywords: pancreas, pancreatic neuroendocrine tumors, PNETs, ATRX, DAXX, ALT, mosaic,

#2093 Genetic Analysis Identifies Subgroups of Small Well-Differentiated Pancreatic Neuroendocrine Tumors with Different Risk for Liver Metastases

Introduction: Small size well-differentiated pancreatic neuroendocrine tumors (PanNETs) behave non-aggressively. However, a limited subset progresses with liver metastases.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Pea A

Authors: Pea A, Yu J, Marchionni L, Noe M, Luchini C,

Keywords: genetic, small tumors, metastases, ALT,

#1186 Significance of ATRX/DAXX Expression and Alternative Lengthening of Telomeres in Insulinomas and Neuroendocrine Tumors of Small Intestine.

Introduction: ATRX and DAXX mutations associated with alternative lengthening of telomeres ( ALT) phenotype have been shown as one of the major altered pathways in pancreatic neuroendocrine tumors (PanNET).

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Neumayer B, Normand L, Hoffmeister M, Friemel J, Perren A,

Keywords: DAXX, ATRX, Alternative lengthening of telomeres, neuroendocrine tumor, Insulinoma,