Abstract Library

#1520 Osteotropism of NETs: Role of the SDF1/CXCR4 Axis in Regulating EMT

Introduction: NETs metastasize to the bone in up to 20% of patients. The SDF1/CXCR4 axis is a key determinant of osteotropism, and we showed that NETs overexpressing CXCR4 are more likely to develop bone metastases.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Cives M

Authors: Simone V, Quaresmini D, D'Oronzo S, Rizzo F, Felici C,

Keywords: emt, cxcr4,

#1065 Functional Role of miR-196a in Neuroendocrine Tumor Cells

Introduction: An exclusive miRNA profiling of small intestinal neuroendocrine tumors (SI-NETs) was published in 2013; and nine miRNAs were selected for further investigations. We chose miR-196a to elucidate its target genes and biological functions, by using NET cells as in vitro models.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Shi H, Li S, Khan M, Caplin M, Meyer T,

Keywords: neuroendocrine tumors, miRNA target genes, miRNA silencing,

#820 ACTG2 Inhibits Growth and Is Epigenetically Repressed in Small Intestinal Neuroendocrine Tumors

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) originate from the enterochromaffin cells in the ileum. Actin gamma smooth muscle 2 (ACTG2) is downregulated in lymph node metastases from SI-NETs. ACTG2 and microRNA-145 (miR-145) are aberrantly expressed in other cancers and ACTG2 can be induced by miRNA-145.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Edfeldt K, Hellman P, Westin G, Stålberg P,

Keywords: SI-NET, ACTG2, miR-145, epigenetics,

#422 The Somatostatin Analogue Octreotide Inhibits Growth of Neuroendocrine Tumor Cells by Triggering Janus Faced Proteins

Introduction: Octreotide is a somatostatin analogue, which improves the management of neuroendocrine tumor (NET) patients. Octreotide acts through somatostatin receptors (SSTRs). However, the molecular mechanisms leading to successful therapy or curative effects are largely unknown, particularly when SSTRs levels are low or absent.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Li S, Martijn C, Cui T, Essaghir A, Luque R,

Keywords: CNDT2.5, Octreotide, neuroendocrine cell growth/differentiation,

#198 Novel Insights in Octreotide Effects on Human Neuroendocrine Cell Line CNDT2.5

Introduction: Octreotide, the first synthetic somatostatin analog available for clinical use, efficiently binds somatostatin receptors (SSRs) 2 and 5 and may transduce its effects by using SSRs.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Li S, Cui T, Martijn C, Öberg K, Giandomenico V,

Keywords: octreotide, human neuroendocrine cell line, CNDT2.5, microarray analysis, somatostatin receptors,