Abstract Library

#4646 Dysregulated miRNA in patients with GEP-NEN and potential role as circulating biomarker

Introduction: Neuroendocrine neoplasms (NENs) are a class of rare and molecularly extremely heterogeneous tumours. NENs arise predominantly in the gastrointestinal (GEP) and pulmonary tracts but can also involve thyroid and breast. NENs often present with non-specific symptoms and lack early specific biomarkers, leading to frequent metastatic diagnoses and primary site challenges.

Conference:

Presenting Author:

Authors: Di Mauro A, Clemente O, Cannella L, Della Vittoria G, Neri G,

Keywords: neuroendocrine tumour, miRNome profiling, biomarker, gep-net, molecular biology,

#3883 Immune landscape in mixed neuroendocrine-non neuroendocrine neoplasms (MiNEN)

Introduction: A mixed neuroendocrine-non neuroendocrine neoplasm (MiNEN) is a novel defined rare entity, made up of two morphologically distinct neoplastic components; one neuroendocrine type (NEN), and the other one non-neuroendocrine type (nNEN). Neuroendocrine differentiation of tumors is thought to influence the tumor microenvironment (TME) through the secretion of various hormones or growth factors.

Conference:

Presenting Author:

Authors: Di Mauro A, Ferrara G, Iervolino D, Scognamiglio G, Clemente O,

Keywords: mixed neuroendocrine, neuroendocrine, tumor microenvironment, immunotherapy, biomarker,

#3872 Mixed neuroendocrine-non neuroendocrine neoplasms (MiNEN): Characterization of the genomic and pathological profile

Introduction: MiNENs is a novel defined rare entity, made up of two morphologically distinct neoplastic components; one neuroendocrine type (NEN), and the other one non-neuroendocrine type (nNEN). As available data are limited, the epidemiology and pathogenesis of MiNENs remain mostly unknown.

Conference:

Presenting Author:

Authors: Di Mauro A, Chianese U, Conte M, Benedetti R, Gerardo F,

Keywords: neuroendocrine, pathogenesis, mixed neuroendocrine, pathway, origin, molecular, molecular analysis, genomic profile,

#3583 Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms (MiNEN): Characterization of the genomic and pathological profile

Introduction: A mixed non-neuroendocrine neoplasm (MiNEN) is a novel defined rare entity, made up of two morphologically distinct neoplastic components; one neuroendocrine type (NEN), and the other one non-neuroendocrine type (nNEN). As available data are limited, the epidemiology and controversial pathogenesis of MiNENs remain mostly unknown.

Conference:

Presenting Author:

Authors: Di Mauro A, Tatangelo F, Conte M, Cantile M, Scognamiglio G,

Keywords: minen neuroendocrine tumor, neuroendocrine, molecular biology, microsatellite instability, oncogenic mechanism, biomarker, oncology, minen tumor, neuroendocrine tumor, genoma sequencing,