Abstract Library

#4113 Establishment of a rat model of diarrhea induced by Surufatinib

Introduction: Surufatinib is a novel oral small-molecule TKI for the treatment of advanced neuroendocrine tumors. However, diarrhea is a common adverse event of surufatinib which can affects patients’ quality of life and clinical efficacy. Currently, there are no available animal models to study the cause and treatmen of surufatinib-related diarrhea.

Conference:

Presenting Author: Hu S

Authors: Hu S, Guo Y, Chen Y, Cheng Z, Deng C,

Keywords: Surufatinib, diarrhea, model, rat,

#1331 The Symptoms Experienced by Small Bowel and Pancreatic NET Patients Prior to Diagnosis Do Not Meet the Criteria for a Functional Diarrhoea (IBS-D) Diagnosis

Introduction: Patients with neuroendocrine tumours (NETs) complain of symptoms that may be mistaken for irritable bowel syndrome (IBS). There is no clear data if these symptoms overlap with those of IBS or if differentiating symptoms co-exist.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Basuroy R, Bouvier C, Sissons M, Ramage J, Srirajaskanthan R,

Keywords: IBS, NET, functional diarrhoea,

#1164 Survival and Predictors of Death for Patients with Bronchopulmonary Carcinoids in a Danish Tertiary NET Center

Introduction: Bronchopulmonary carcinoids (BC) represent 1% of lung cancers and comprise typical (TC) and atypical carcinoids (AC).

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Kornerup L, Dam G, Grønbæk H,

Keywords: Bronchopulmonary carcinoid, typical, atypical, neuroendocrine, KI67 index,

#884 Simultanenous Duplicate Malignant Disease-Adenocarcinoma of the Colon and Disseminated Neuroendocrine Tumor

Introduction: Fifty-nine-year old man, under examination due to weight loss, enterorrhagia, general abdominal discomfort. Endoscopy detected tumorous infiltration 20 cm from the anus, bleeding. Histology: adenocarcinoma. CT abdomen detected liver lesion. The lesion was hypervascularized, and the CT picture was atypical for metastatic adenocarcinoma. CT chest: tumor lesion in the left lower segment, metastatic LN in mediastinum. According to the CT, the picture is atypical for metastases.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Ostrizkova L

Authors: Ostrizkova L, Brancikova D, Mechl Z, Cerny I, Kala Z,

Keywords: duplicate malignant disease,

#121 Serotonin synthesis inhibitors: a novel approach for managing gastrointestinal symptoms in carcinoid syndrome

Introduction: Carcinoid syndrome (CS) occurs when metastatic carcinoid tumors secrete large amounts of serotonin (5-HT) and other bioactive substances into systemic circulation, causing a variety of symptoms, including GI symptoms such as profound diarrhea. Reduction in 5-HT production by the tumor would be expected to improve symptoms in patients with CS.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Brown P

Authors: Brown P, Jackson J, Frazier K, Turnage A, Clark E,

Keywords: carcinoid syndrome, TPH inhibitor, 5-HT, tryptophan hydroxylase, clinical trial, serotonin synthesis, serotonin synthesis inhibitor, LX1032, LX1031, Lexicon, IBS, irritable bowel syndrome, SSI,