Abstract Library

#2297 Merkel Cell Carcinomas in New Zealand: Virus or Ultra Violet?

Introduction: Merkel Cell Carcinoma (MCC) is a rare Neuroendocrine skin tumour. MCC behavior is more aggressive than the more common Melanoma, with treatments often restricted to surgery or radiotherapy, although immunotherapy holds promise overseas. In 2008, a USA study identified an oncogenic polyomavirus (MCPyV) present in eight of ten tested MCC tumours. Studies from across Europe and the USA confirmed MCPyV presence in ~80% of all MCCs. However, a cohort from Australia found a rate of just 24%, suggesting an alternative mechanism; ultra violet (UV) exposure was suspected and later confirmed using genomic mutational signature analysis. Are these are two separate diseases, requiring different clinical management strategies for best patient outcomes?

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Robb T

Authors: Robb T, Woodhouse B, Parker K, Miller R, Hayward G,

Keywords: merkel, ddPCR, diagnostics, genomics,

#2281 A Novel Classification of Pancreatic Neuroendocrine Tumors (pNETs) Guided by Genomics

Introduction: NET outcomes differ by primary site. Yet pNETs are classified using a generic GI grading system.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Lawrence B

Authors: Lawrence B, Blenkiron C, Parker K, Yeong M, Kramer N,

Keywords: pancreatic NET, genomics,

#2272 Enhancing Diagnostic Precision Through Combined Genomic and Histopathological Analysis of Pancreatic Neuroendocrine Tumors

Introduction: Diagnostic differentiation of uncommon pancreatic malignancies can be challenging, but is essential for accurate clinical management; genomic analysis may provide a tool for making this critical distinction.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Lawrence B

Authors: Robb T, Yeong M, Kramer N, Blenkiron C, Parker K,

Keywords: precision medicine, diagnostics, histology, pathology, histo-pathology, genomics,

#2229 The NETwork! Registry Suggests Increasing Incidence in a National Study of Neuroendocrine Cancer in New Zealand (NZ)

Introduction: NETwork! is a clinical and translational research program, including a retrospective epidemiological study of NETs in NZ.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Parker K

Authors: Parker K, Coats E, Woodhouse B, Knowlton N, Print C,

Keywords: neuroendocrine, incidence, epidemiology, registry,

#2226 Approaching NETs from Many Angles: A Medical Research Paradigm to Challenge New Zealand’s Research Traditions

Introduction: NETwork! is a multidisciplinary clinical and translational research program investigating NETs from several perspectives.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Parker K

Authors: Parker K, Blenkiron C, Print C, Findlay M, Lawrence B,

Keywords: neuroendocrine, translational, multidisciplinary,