Abstract Library

#4592 Uncovering cell-state heterogeneity in large-cell panNEC indicates potentially targetable aberrant brain type neuronal de-differentiation

Introduction: Classification and treatment of high-grade pancreatic neuroendocrine carcinoma (panNEC), particularly those with large-cell morphology, present significant clinical challenges due to considerable inter- and intra-patient tumour heterogeneity.

Conference:

Presenting Author: Debnath O

Authors: Debnath O, Berger H, Detjen K, Kirchner P, Marinoni I,

Keywords: pancreatic neuroendocrine carcinoma, single cell, personalised medicine,

#4502 Molecular analysis of non-functioning PanNETs of the alpha lineage reveals new subtypes and mechanisms of progression

Introduction: Most pancreatic neuroendocrine tumours (PanNETs) are non-functioning. Previously, we demonstrated that small, MEN1-only mutated α-like PanNETs can be distinguished from larger ADM (mutated in ATRX, DAXX and MEN1) PanNETs based on epigenetic profiles. ADM PanNETs have shorter disease-free survival and a higher relapse risk. However, their therapeutic responses vary, underscoring group heterogeneity. ADM PanNETs remain insufficiently characterised, with potential subtype-specific progression drivers with implications for treatment choice and clinical outcome.

Conference:

Presenting Author: Avanthay S

Authors: Avanthay S, Di Domenico A, Kirchner P, Bräutigam K, Chouchane A,

Keywords: pancreas, epigenetics, progression, metastasis, DAXX, ATRX, Pan NET,

#4403 Ki-67 index cut-off values and survival prognostication in neuroendocrine neoplasms: Machine learning-based insights

Introduction: The current grading system for gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) is based on Ki-67 index and/or mitotic rate. By definition, high-grade NEN (neuroendocrine tumour grade 3 [NET G3] and neuroendocrine carcinoma [NEC]) have a Ki-67 >20%, while NET G1 have a Ki-67

Conference:

Presenting Author:

Authors: Melhorn P, Berchtold L, Mazal P, Raderer M, Kiesewetter B,

Keywords: neuroendocrine neoplasm, prognosis, ki-67 index,

#4321 Insulinoma – A diagnostic challenge

Introduction: Insulinomas are rare pancreatic neuroendocrine neoplasms (pNEN). Operative resection is the treatment of choice.

Conference:

Presenting Author:

Authors: Ritter A, Poppinga J, Steinkraus K, von Kroge P, Amin T,

Keywords: Neuroendocrine neoplasia, insulinoma, pancreatic NEN, hypoglycaemia,

#4300 A retrospective comparison of preoperative characteristics and surgical outcomes in small intestine neuroendocrine neoplasms (SiNENs) and small intestine adenocarcinoma

Introduction: SiNENs are complex tumours with unique behaviour. Despite 30 years of progress, limited data and diagnostic challenges hinder understanding, complicating assessment of their biology and outcomes.

Conference:

Presenting Author: Zamparas A

Authors: Herzog T, Zamparas A, Uhl W, Strotmann J, Höhn P,

Keywords: small intestine NEN, small bowel adenocarcinoma, NET, Chromogranin A, 5-year follow-up, 10-year follow-up,