Abstract Library

#4329 Multivariate survival analyses of 544 advanced high-grade digestive neuroendocrine neoplasms (NET G3 and NEC) given first-line chemotherapy (NORDIC NEC 2)

Introduction: Digestive high-grade neuroendocrine neoplasms (HG-NEN) are rare and consist of neuroendocrine tumours G3 (NET G3) and neuroendocrine carcinomas (NEC). They differ in clinical and molecular characteristics, response to treatment and prognosis. Limited prospective data are available on prognostic factors for survival in patients given first-line chemotherapy outside of clinical trials.

Conference:

Presenting Author:

Authors: Sorbye H, Hjortland G, Vestermark L, Ladekarl M, Svensson J,

Keywords: neuroendocrine neoplasm, neuroendocrine carcinoma, digestive, high-grade, neuroendocrine tumour grade 3,

#3965 Nordic NEC 2: Characteristics and treatment outcome in a prospective cohort of 698 patients with high-grade digestive neuroendocrine neoplasms (NET G3 and NEC)

Introduction: Digestive high-grade (HG) neuroendocrine neoplasms (NEN) are rare with limited data on epidemiology, treatment benefit and survival.

Conference:

Presenting Author:

Authors: Sorbye H, Hjortland G, Vestermark L, Laderkarl M, Svensson J,

Keywords: NEC, NET G3, digestive, chemotherapy, neuroendocrine neoplasms,

#3866 Treatment efficacy in 212 metastatic small intestinal neuroendocrine tumor grade 2 patients

Introduction: Small intestinal neuroendocrine tumors (Si-NET) are frequently studied as a single entity, irrespective of their grade, which is known to influence prognosis.

Conference:

Presenting Author: Papantoniou D

Authors: Papantoniou D, Grönberg M, Thiis-Evensen E, Sorbye H, Landerholm K,

Keywords: small intestinal neuroendocrine tumor, grade 2, somatostatin analogues, PRRT, Ki-67, somatostatin-receptor negative,

#3717 Results of NETest liquid biopsy in high-grade gastroenteropancreatic neuroendocrine neoplasms

Introduction: Molecular blood biomarkers are lacking for high-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN), and morphologically separating between neuroendocrine carcinoma (NEC), neuroendocrine tumors (NET G3), adenocarcinoma and MINEN frequently difficult. The mRNA-based NETest has diagnostic, prognostic and predictive value in neuroendocrine tumors G1-2 but has not been studied in HG GEP-NEN.

Conference:

Presenting Author: Sorbye H

Authors: Sorbye H, Langer S, Hjortland G, Vestermark L, Sundlov A,

Keywords: NETest, high-grade, gastroenteropancreatic, neuroendocrine carcinoma, NET G3, neuroendocrine neoplasm, biomarker,

#3712 Germline pathogenic variants in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms

Introduction: High-grade gastroenteropancreatic (HG-GEP) neuroendocrine neoplasms (NEN) are aggressive cancers with a dismal prognosis. The molecular etiology remains poorly characterized and prevalence of pathogenic germline variants unknown.

Conference:

Presenting Author: Sorbye H

Authors: Sorbye H, Venizelos A, Perren A, Couvelard A, Hjortland G,

Keywords: germline, mutations, gastropancreatic, neuroendocrine carcinoma, NET G3, high-grade,