Abstract Library

#4656 Development of a 3D patient-derived extracellular matrix hydrogel model of small intestinal neuroendocrine tumour and mesenteric fibrosis

Introduction: The pathogenesis of mesenteric fibrosis in small intestinal neuroendocrine tumours (SI-NETs) is poorly understood, limiting development of effective treatments and biomarkers. A major barrier to research is the lack of disease models.

Conference:

Presenting Author:

Authors: Hodgetts H, Martins M, Luong T, Hall A, Webster A,

Keywords: small intestine, neuroendocrine, 3D model, hydrogel, fibrosis,

#4350 Cytoendoscopy for determining the depth of invasion and metastasis of rectal neuroendocrine tumours

Introduction: Rectal neuroendocrine tumours (rNETs) are relatively common submucosal tumours, but even low-grade rNETs can metastasise. The significance of endocytology (EC) in the clinical evaluation of rNETs has not been reported.

Conference:

Presenting Author: Tang Q

Authors: Bai J, Tian Y, Tang Q,

Keywords: rectal neuroendocrine tumour, cytoendoscopy, invasion, metastasis, tumour grade,

#4146 Anticancer activity of Cabozantinib and Temozolomide in cell lines derived from lung carcinoid and pancreatic neuroendocrine tumors

Introduction: Limited therapeutic options are available for patients with advanced neuroendocrine neoplasms (NENs). Cabozantinib (CBZ), a tyrosine kinase inhibitor including c-MET pathway, and Temozolomide (TMZ), an alkylating agent enhancing the anti-angiogenic effect of CBZ, are emerging as promising treatments in NENs.

Conference:

Presenting Author:

Authors: Tornesello M, Starita N, Clemente O, Cerasuolo A, Bracigliano A,

Keywords: cabozantinib, temozolomide, neuroendocrine tumor, cell lines, in vitro study,

#4041 Mesenteric fibrosis in small intestinal neuroendocrine tumors (SI-NETs): Pathogenesis and therapeutic targets

Introduction: Mesenteric fibrosis (MF) affects up to 50% of small intestine neuroendocrine tumor (SI-NET) patients, causing significant morbidity and mortality. MF pathophysiology is poorly understood, limiting treatment development and biomarker identification.

Conference:

Presenting Author:

Authors: Castanho Martins M, Hodgetts H, Lemos Dias M, Luong T, Hall A,

Keywords: fibrosis, small intestine, 3D model, cell crosstalk, microenvironment, cancer-associated fibroblast,

#3367 Integrating Saffron’s Metabolomics on Neuroblastoma Treatment

Introduction: Crocus sativus (saffron) is endowed with anticancer, antioxidant and genoprotective properties. Its pharmacological properties are attributed to the hydrophilic carotenoids crocins (CRCs), which are glycosy-esters of crocetin (CRT). The hemisynthetic derivate dimethylcrocetin (DMCRT) is similar to CRT.

Conference:

Presenting Author:

Authors: Hatziagapiou K, Nikola O, Koniari E, Chrousos G, Kanaka-Gantenbein C,

Keywords: saffron, crocins, dimethylocrocetin, neuroblastoma, cytotoxicity, apoptosis,