Abstract Library

#4200 Risk of venous thromboembolism according to molecular profiling in patients with neuroendocrine carcinoma

Introduction: Venous thromboembolism (VTE) is a common complication in cancer patients, which negatively affects prognosis. Neuroendocrine carcinomas (NEC) are a rare and aggressive diseases, with low responses to treatment and poor prognosis. In this context, the use of molecular profiling is crucial for the identification of druggable alterations. However, data about VTE in NENs are scares, even though retrospective data describes rates in line with other high-risk malignancies.

Conference:

Presenting Author:

Authors: Gervaso L, Winchler C, Pisa E, Benini L, Cella C,

Keywords: VTE, NEC, molecular profiling, neuroendocrine carcinoma, venous thromboembolism,

#3821 Risk of venous thromboembolism in pancreatic neuroendocrine neoplasms

Introduction: Venous thromboembolism (VTE) is a leading cause of morbidity and death in cancer. The incidence of VTE is increased in different cancers such as pancreatic ductal adenocarcinoma, however limited evidence is present this risk for pancreatic neuroendocrine neoplasms (pan-NENs).

Conference:

Presenting Author: Gervaso L

Authors: Gervaso L, Laffi A, Cella C, Rubino M, Spada F,

Keywords: Venous thromboembolism, pancreatic neuroendocrine tumor, pancreatic neuroendocrine carcinoma, NEN, VTE,

#3804 Wide molecular analysis of PanNET revealed that only MGMT promoter methylation seemed to correlate with Temozolomide response

Introduction: Temozolomide (TMZ) is an alkylating agent and is widely used in the treatment of PanNET. So far, only the MGMT status, defined by its immunohistochemical (IHC) expression or its promoter methylation, has been proposed as predictor of response to TMZ, but its value remains controversial.

Conference:

Presenting Author: Marinoni I

Authors: Cives M, Kirchner P, Palmirotta R, Lauricella E, de Mestier L,

Keywords: PanNET, Temozolomide, MGMT,

#3724 Tackling drug activity and resistance mechanisms in neuroendocrine tumors treated with cabozantinib

Introduction: Neuroendocrine tumors (NETs) are highly vascularized malignancies and angiogenesis plays a relevant role in cell proliferation and survival. Nowadays, innovative therapies have amplified the paradigm treatment of NETs. Among the compounds with anti-vascular properties, cabozantinib (CAB) appeared promising.

Conference:

Presenting Author: Cella C

Authors: Cella C, Cazzoli R, Fazio N, de Petro G, Gaudenzi G,

Keywords: Neuroendocrine tumor, angiogenesis, zebrafish model, mouse model.,

#3266 The psychological impact of COVID-19 pandemic in patients with NETs: Between resilience and vulnerability

Introduction: The COVID-19 pandemic has dramatically changed lifestyles and quality of life (QoL) of the global population. Little is known regarding the psychological impact of COVID-19 in patients with gastroenteropancreatic (GEP) or bronchopulmonary (BP) NETs.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Lauricella E

Authors: Lauricella E, Cives M, Bracigliano A, Lamia S, Felici V,

Keywords: covid-19, net, depression, anxiety, quality of life,