Abstract Library

#4660 Clinical significance of interval imaging in patients with well-differentiated neuroendocrine neoplasms (NENs) receiving peptide receptor radionuclide therapy (PRRT)

Introduction: PRRT is an effective therapy for advanced NENs with SSTR-avid disease, however, the role of interval imaging in between PRRT cycles and its benefit is unknown.

Conference:

Presenting Author:

Authors: Grewal U, Patel R, Chandasekharan C,

Keywords: Peptide receptor radionuclide therapy, interval imaging, neuroendocrine tumour,

#4568 Investigating the dual role of SNW1 in splicing and transcription to understand pancreatic neuroendocrine tumour progression

Introduction: Pancreatic neuroendocrine tumours (PanNETs) are classified into grades (G1-G3) based on mitotic rate, with higher grades exhibiting increased dedifferentiation and invasiveness. Despite the clinical significance of PanNETs progression, the underlying mechanisms remain largely unexplored. We have previously reported that altered alternative splicing plays an essential role in PanNETs progression, where SNW1, a key regulator of splicing and transcription, was found to be overexpressed in tumour tissue, correlating with higher grade and recurrence risk.

Conference:

Presenting Author: González-Pérez C

Authors: González-Pérez C, Simón-Lesnyak M, Blázquez-Encinas R, García Vioque V, Moreno Montilla M,

Keywords: pancreas, neuroendocrine tumour, progression, SNW1, splicing,

#4491 Expression and clinical significance of IGFBP-3 in pituitary neuroendocrine tumours

Introduction: IGFBP-3 is a regulatory factor highly expressed in pituitary neuroendocrine tumours that may provide reference for the clinical diagnosis and treatment of pituitary neuroendocrine tumours.

Conference:

Presenting Author:

Authors: Hu Y, Yuan C, Tang Y,

Keywords: IGFBP-3, Pituitary neuroendocrine tumour,

#4465 RET Lys666Asn has low MEN2-related tumours penetrance but may be associated with pheochromocytoma

Introduction: Multiple Endocrine Neoplasia type 2 (MEN2) is caused by germline pathogenic variants (PVs) in the RET proto-oncogene, leading to medullary thyroid carcinoma (MTC), pheochromocytoma, and primary hyperparathyroidism (PHPT). RET c.1998G>C, p.Lys666Asn is a rare PV, with 33 cases described thus far, and is associated with low penetrance of MEN2-related tumours, but its clinical significance remains incompletely understood.

Conference:

Presenting Author: Halperin R

Authors: Halperin R, Peshes-Yaloz N, Tirosh A, Twito O,

Keywords: MEN2, pheochromocytoma, hyperparathyroidism, medullary thyroid carcinoma,

#3987 m6A modifications promote the invasion and metastasis of pancreatic neuroendocrine neoplasms by activating the Integrin/FAK signalling pathway via TGFBI

Introduction: Nearly 50% of patients with pNENs have metastases at the time of initial diagnosis, and there is a lack of effective treatment once they have metastases. The 5-year overall survival rate for G3 pNENs with metastasis at diagnosis was 0, which was significantly lower than that for patients without metastasis, with a 5-year overall survival rate of 43%. At present, the pathogenesis of pNENs has not been clarified.

Conference:

Presenting Author:

Authors: Ye M, Tang Q,

Keywords: RNA methyltransferases, Tumor metastasis, Pancreatic neuroendocrine neoplasm, Transforming growth factor-β-induced gene, Integrin/FAK signaling pathway,