Abstract Library

#4369 The predictive value of 68Ga-DOTANOC, 18F-DOPA, and 18F-FDG PET/CT in patients with paragangliomas

Introduction: Paragangliomas (PGLs) are rare neuroendocrine tumours with variable clinical outcomes. Early identification of prognostic markers is essential for effective disease management. PET/CT imaging with 68Ga-DOTANOC, 18F-DOPA, and 18F-FDG offers unique insights into tumour biology, respectively.

Conference:

Presenting Author: Xu J

Authors: Gao J, Xu J, Liang Y, Chen J, Song S,

Keywords: PET/CT, paraganglioma, prognosis,

#4327 Metastatic non-functional pancreatic neuroendocrine tumour with transformation to insulinoma shown on 68Ga-Exendin-4 PET/CT

Introduction: 68Ga-exendin-4 PET/CT imaging has been utilised for benign insulinomas. However, some reports demonstrated the absence of GLP-1R expression of malignant insulinomas.

Conference:

Presenting Author:

Authors: Gao J, Xu J, Liang Y, Chen J, Song S,

Keywords: pancreatic neuroendocrine tumour, PET/CT, insulinoma, 68Ga-exendin-4,

#4166 Characterising the tumor microenvironment of multifocal small intestinal NETs

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) are thought to arise from enterochromaffin cells of the gut, often with multiple synchronous primary tumors. Recently, we showed that synchronous primary tumors from the same SI-NET patient display distinct somatic mutational profiles, suggesting that these tumors originate independently, despite few clear driver mutations. Thus, new mechanistic insights into multifocal SI-NETs are urgently needed.

Conference:

Presenting Author:

Authors: Mäkinen N, Lee I, Dohlman A, Gao T, Zhang Z,

Keywords: small intestinal NET, tumor microenvironment, tumor microbiome,

#3827 Prevalence of Clonal Hematopoiesis (CH) in neuroendocrine tumor (NET) patients prior to Lutetium 177 dotatate therapy (Lu177) and the risk of cytopenia – A prospective study of 37 patients

Introduction: Lu177 has shown efficacy in advanced NET but with significant hematologic toxicity, including therapy-related myeloid neoplasm (t-MN). CH is defined by acquisition of somatic mutations in hematopoietic stem cells with potential for expansion over time.

Conference:

Presenting Author: Sonbol M

Authors: Sonbol M, Kusne Y, Lasho T, Elsabbagh Z, Mangaonkar A,

Keywords: clonal hematopoiesis, neuroendocrine, PRRT, Lu177, t-MN, CHIP,

#3425 Diagnostic role and prognostic value of tumor markers in high-grade GEP-NENs

Introduction: High-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) can be divided into well differentiated neuroendocrine tumors G3 (NETs G3) and poorly differentiated neuroendocrine carcinomas (NECs). Diagnostic and prognosis value of tumor markers in this entity still remains unknown.

Conference:

Presenting Author: Gao C

Authors: Gao C, Fan Z, Yang J, Shi M, Liu S,

Keywords: CA-19-9 Antigen, Carcinoembryonic Antigen, overall survival, gastroenteropancreatic neuroendocrine neoplasm,