Abstract Library

#4066 Immune landscape of small intestinal neuroendocrine tumor at single-cell level

Introduction: Small intestinal neuroendocrine tumor (SI-NET) is the most common malignant tumor of the small intestine. Despite its prominence, a full understanding of the immune landscape in SI-NET remains elusive.

Conference:

Presenting Author: Lin X

Authors: Lin X, Chen L, Liu M, Li Y, Wen W,

Keywords: small intestinal neuroendocrine tumor, single-cell RNA sequencing, immunosuppressive, CD8 T cells, TGFB1,

#3883 Immune landscape in mixed neuroendocrine-non neuroendocrine neoplasms (MiNEN)

Introduction: A mixed neuroendocrine-non neuroendocrine neoplasm (MiNEN) is a novel defined rare entity, made up of two morphologically distinct neoplastic components; one neuroendocrine type (NEN), and the other one non-neuroendocrine type (nNEN). Neuroendocrine differentiation of tumors is thought to influence the tumor microenvironment (TME) through the secretion of various hormones or growth factors.

Conference:

Presenting Author:

Authors: Di Mauro A, Ferrara G, Iervolino D, Scognamiglio G, Clemente O,

Keywords: mixed neuroendocrine, neuroendocrine, tumor microenvironment, immunotherapy, biomarker,

#3322 Analysis of immune landscape in pancreatic and ileal neuroendocrine tumors demonstrates an immune cold tumor microenvironment

Introduction: Neuroendocrine tumors (NETs) are rare tumors with an increasing incidence. While low and intermediate-grade pancreatic (PNET) and ileal (INET) tumors are slow-growing, they have a relatively high rate of metastasis to the liver where the outcome is much worse. For most cancers, the outcome is determined by the quality of the anti-tumor immune response. However, the quality and significance of anti-tumor responses in NETs are incompletely understood.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Tanno L, Naheed S, Dunbar J, Tod J, Lopez M,

Keywords: pancreatic neuroendocrine tumor, ileal neuroendocrine tumor, tumor immune microenvironment, tumor infiltrating lymphocytes,

#3184 Immune heterogeneity and cascade of changes in subtypes of pancreatic neuroendocrine tumors

Introduction: Previously, we published four molecular subtypes of pancreatic neuroendocrine tumors (PanNETs) - met-like primary (MLP)-1 and -2, intermediate and insulinoma- like with different clinical and molecular characteristics. While immunotherapy trials are on-going in PanNETs, the immune landscape of this disease is largely unknown.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Sadanandam A

Authors: Sadanandam A, Young K, Lawlor R, Ragulan C, Patil Y,

Keywords: pancreatic neuroendocrine tumor, immune microenvironment, viral-mimicry pathway, pancreatic cancer, computational methods, T cells, macrophages, immunotherapy, B cells, complement pathway, interferon signalling, STING pathway, hypoxia, necroptosis, tumor ,

#2199 Systematic Evaluation of the Immune Microenvironment of Neuroendocrine Tumors (NET)

Introduction: Immunotherapy is being explored in many tumour types with encouraging results, but its role in the management of NET is yet to be defined.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Vesely C

Authors: Vesely C, Childs A, Wong Y, Ogunbiyi O, Gander A,

Keywords: immunotherapy, neuroendocrine tumor, immune landscape, checkpoint molecules, t cells,