#3132
Plasmatic and urinary 5-hydroxyindolacetic acid measurements in patients with midgut neuroendocrine tumors: A GTE study
Introduction:
Although 24-hour urinary 5-hydroxyindolacetic acid (24u5HIAA) is a key biomarker in midgut NET, it may be inaccurate and inconvenient.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
de Mestier L
Authors:
de Mestier L,
Savagner F,
Brixi H,
Do Cao C,
Dominguez S,
Keywords:
neuroendocrine tumor,
carcinoid syndrome,
5-hydroxyindolacetic acid,
biomarker,
diagnosis,
#121
Serotonin synthesis inhibitors: a novel approach for managing gastrointestinal symptoms in carcinoid syndrome
Introduction:
Carcinoid syndrome (CS) occurs when metastatic carcinoid tumors secrete large amounts of serotonin (5-HT) and other bioactive substances into systemic circulation, causing a variety of symptoms, including GI symptoms such as profound diarrhea. Reduction in 5-HT production by the tumor would be expected to improve symptoms in patients with CS.
Conference:
7th Annual ENETSConcerence (2010)
Presenting Author:
Brown P
Authors:
Brown P,
Jackson J,
Frazier K,
Turnage A,
Clark E,
Keywords:
carcinoid syndrome,
TPH inhibitor,
5-HT,
tryptophan hydroxylase,
clinical trial,
serotonin
synthesis,
serotonin synthesis inhibitor,
LX1032,
LX1031,
Lexicon,
IBS,
irritable bowel syndrome,
SSI,