Abstract Library

#4166 Characterising the tumor microenvironment of multifocal small intestinal NETs

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) are thought to arise from enterochromaffin cells of the gut, often with multiple synchronous primary tumors. Recently, we showed that synchronous primary tumors from the same SI-NET patient display distinct somatic mutational profiles, suggesting that these tumors originate independently, despite few clear driver mutations. Thus, new mechanistic insights into multifocal SI-NETs are urgently needed.

Conference:

Presenting Author:

Authors: Mäkinen N, Lee I, Dohlman A, Gao T, Zhang Z,

Keywords: small intestinal NET, tumor microenvironment, tumor microbiome,

#4112 Sexual dimorphism in small intestinal NETs: Any association with development of mesenteric metastases?

Introduction: Small-intestinal neuroendocrine tumors (SI-NET) are rising in incidence and complications such as mesenteric and hepatic metastases are associated with increased morbidity and mortality. It has recently been suggested that mesenteric metastases risk increases in women around menopause.

Conference:

Presenting Author: Castanho Martins M

Authors: Hassan D, Bally D, Castanho Martins M, Hodgetts H, Rombouts K,

Keywords: small intestine, mesenteric metastases, mesenteric fibrosis, sexual dimorphism, sex hormone,

#3995 Pelvic metastases in patients with neuroendocrine tumors: A rare site of metastases

Introduction: Pelvic metastases (PMs) in patients with neuroendocrine tumors (NETs) are rare and develop predominately in women with small intestinal NETs (Si-NETs). The characteristics of NET related PMs and the efficacy of different management options have been poorly investigated.

Conference:

Presenting Author:

Authors: Thuringer J, Tsoli M, Parker G, Sarma A, Panagaki M,

Keywords: pelvic metastases, prognosis, oophorectomy, PRRT,

#3644 N-terminal pro-brain natriuretic peptide and chromogranin A as biomarkers for detection of carcinoid heart disease

Introduction: Carcinoid heart disease (CHD) is a serious complication for patients with neuroendocrine tumors (NETs), and early detection is crucial.

Conference:

Presenting Author: Lau T

Authors: Lau T, Johnson K, Oksjoki R, Baunwall S, Villadsen G,

Keywords: carcinoid heart disease, probnp, 5-hiaa, cga, biomarker,

#913 A PCR-Based Multigene Transcript Analysis Blood Test Outperforms Chromogranin A in the Detection of Gastrointestinal and Pancreatic Neuroendocrine Tumors and is Unaffected by PPI Use or Hypertension

Introduction: A critical requirement in the management of gut NETs is a blood biomarker test that is sensitive, specific and reproducible.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Modlin I

Authors: Modlin I, Kidd M, Drozdov I, Aslanian H, Alaimo D,

Keywords: biomarker, CgA, NET, PCR,