Abstract Library

#4536 Follow-up is not justified in patients with typical lung carcinoids treated with curative intent

Introduction: Typical carcinoids (TC) are well-differentiated neuroendocrine neoplasms of the lung with generally favourable prognosis. Recurrence is rare in TC patients treated with curative intent, yet current ENETS guidelines recommend extensive follow-up, including regular and long-term imaging.

Conference:

Presenting Author: Lau T

Authors: Lau T, Soldath P, Rewitz K, Jepsen P, Knigge U,

Keywords: typical carcinoid, lung nen, follow-up programme,

#4201 Prospective analysis of the risk of post-surgical recurrence in lung typical carcinoid

Introduction: In localized/locally advanced forms of NET, radical surgical resection represents the standard of care.

Conference:

Presenting Author:

Authors: Paravani P, Russo F, Mazzilli R, Zamponi V, Mancini C,

Keywords: Lung typical carcinoid, recurrence-free-survival, Ki-67%, Male sex, Mitotic Index, TTF-1, Surgery,

#3972 Machine-learning identified optimised classification models for the diagnosis of typical and atypical lung carcinoids based on the genomic variance

Introduction: The current diagnosis of lung typical carcinoids (TCs) and atypical carcinoids (ACs) can be ambiguous for small biopsies containing limited tissues.

Conference:

Presenting Author: Guo Y

Authors: Guo Y, Su F, Hu S, Chen R, Chen Q,

Keywords: lung carcinoid, typical carcinoid, atypical carcinoid, machine-learning, diagnosis, genomic features,

#3961 Enhancer heterogeneity of lung carcinoids reveals sensitivity to FGF signaling inhibition

Introduction: Well-differentiated low grade lung carcinoids are histo-pathologically classified as typical and atypical, but each subtype is still heterogenous both at the molecular level and its clinical manifestation. Therefore, the treatment of these patients is challenging. The two main challenges are the lack of effective drug treatments and the lack of reliable biomarkers to guide management since the disease in patients with the same tumor grade/stage often has different clinical courses. The genetic, epigenetic, and developmental programs that drive lung carcinoids remain obscure, limiting our abilities to suggest new biomarkers and drug targets.

Conference:

Presenting Author: Drier Y

Authors: Davis E, Avniel-Polak S, Hecht M, Grozinsky-Glasberg S, Drier Y,

Keywords: FGF Signaling, Lung carcinoids, Enhancers,

#3652 Features of the expression of TTF-1 and Cytokeratin 19 as a predictor of a less favourable prognosis of atypical lung carcinoids

Introduction: Atypical lung carcinoids are a highly heterogeneous group of tumors, some of which have more malignant potential, which makes the search for additional morphological prognostic criteria relevant.

Conference:

Presenting Author:

Authors: Gurevich L, Bondarenco E, Markarova E, Kagoniya L,

Keywords: lung carcinoid, atypical, prognosis, TTF1, cytokeratin 19,