Abstract Library

#4176 A single center experience of locoregional treatments application in neuroendocrine liver metastases

Introduction: Gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) are complicate with neuroendocrine hepatic metastasis (NELM) in approximately 60% of cases. Loco-regional interventional radiology procedures are widely approved in treatment of hepatocellular carcinoma (HCC) and in last years found more and more application in liver metastasis.

Conference:

Presenting Author: Ferretti S

Authors: Masoni B, Ferretti S, Rossi R, Ceriani R, Laffi A,

Keywords: neuroendocrine, loco regional treatment, liver metastasis, interventional radiology, embolization, ablation,

#3398 Patient-derived tumoroids phenocopy original gastro-entero-pancreatic neuroendocrine neoplasms and facilitate in vitro drug screening

Introduction: GastroEnteroPancreatic Neuroendocrine Neoplasms (GEP-NENs) are rare cancers that appear clinically and biologically extremely heterogenous. While highly proliferative cases are invariably lethal, slower-proliferating NENs—representing predominant cases—have unpredictable clinical courses varying from indolent to malignant. Recent comprehensive NGS screens in patients helped to extend our understanding. However, complementary relevant preclinical models to address disease heterogeneity and to investigate patient-specific treatment alternatives are still inexistent.

Conference:

Presenting Author: April-Monn S

Authors: April-Monn S, Kirchner P, Detjen K, Gloor B, Partelli S,

Keywords: GEP-NEN, Organoid, Tumoroid, Model, Drug screening, translational, single-cell RNAseq, NGS, OMICs, biomarker,

#3019 Incomplete Peptide Receptor Radionuclide Therapy Courses - Are We Selecting Our Patients Appropriately?

Introduction: As per recommendations, a Peptide Receptor Radionuclide Therapy (PRRT) with Lu-177 DOTATATE course usually consists of 4 cycles. Patients may discontinue a PRRT course early, either due to progression or toxicity. Limited data are available about predictive factors for PRRT early discontinuation.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Julian G

Authors: Gertner J, Groves J, Aziz B, Miah L, Furtado O'Mahony L,

Keywords: prrt,

#2841 Novelties in Primary and Metastatic GEP-NENs Clinical Outcome Investigation

Introduction: Gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) WHO classification, using strict cut-offs, should reflect their biological features. In real world, strict cut-offs not adequately segregate prognostic groups, in particular on metastasis (M).

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Milione M

Authors: Kankava K, Maisonneuve P, Mangogna A, Centonze G, Cattaneo L,

Keywords: Gastro-entero-pancreatic neuroendocrine neoplasms, primary tumor, metastasis, Ki-67, mitoses, tumor deposits, clinical outcomes,

#2784 Predictive Factors of Tumor Recurrence after Radical Surgery for Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NENs): Identification of High-Risk Subgroups

Introduction: There is no proven role for adjuvant medical therapy after curative surgery (R0) for GEP-NENs.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Rossi R

Authors: Rossi R, Altomare M, Monteleone M, Prinzi N, Pusceddu S,

Keywords: radical surgery, recurrence, gastro-entero-pancreatic neuroendocrine neoplasms, prognostic factors,