Abstract Library

#4496 ATRX, DAXX, and menin immunohistochemistry identify prognostic relevant non-functioning neuroendocrine tumours subgroups

Introduction: Non-functioning pancreatic neuroendocrine tumours (NF-pNETs) are rare tumours with a variable prognosis. Recent studies have identified prognostic subgroups based on ATRX, DAXX and MEN1 mutations along with chromosomal aneuploidies.

Conference:

Presenting Author: Verschuur A

Authors: Verschuur A, Jairam J, Eldem B, Singhi A, Hackeng W,

Keywords: pancreatic neuroendocrine tumour, ATRX, DAXX, MEN1, menin, biomarker,

#4430 Long-term prognosis of parenchyma-sparing vs. oncologic resections for distal pancreatic non-functional neuroendocrine tumours ≤ 3cm: A real-world data study (CSPAC-NEN-5)

Introduction: Studies show that parenchyma-sparing resections (PSR) for small, non-functional pancreatic neuroendocrine tumours (NF-pNETs) provide long-term outcomes similar to oncologic resections (OR). However, these studies have not fully considered location-based differences in surgical approach and lymphatic drainage.

Conference:

Presenting Author: Li Z

Authors: Li Z, Ji S, Chen J, Xu X, Yu X,

Keywords: pancreatic neuroendocrine, parenchyma-sparing resection, recurrence-free survival,

#4292 Predictors based on the radiologic characteristics for aggressiveness of small (＜20 mm) non-functioning pancreatic neuroendocrine tumours

Introduction: The management of small non-functioning PNETs remains controversial due to their heterogeneity. Results from some retrospective surgical reports found that a subset of small NF-PNETs may show aggressive behaviour, for which surgical resection is recommended.

Conference:

Presenting Author: Shu-Jie R

Authors: Ren S, Fan Y, Tan C, Wang X, Tan Q,

Keywords: small pancreatic neuroendocrine tumour, high-risk factor, radiologic characteristics, tumour marker, prognostic factor,

#3942 A nomogram to preoperatively predict the aggressiveness of non-functional pancreatic neuroendocrine tumors based on CT features

Introduction: Most NF-pNETs are diagnosed incidentally, it’s a challenge for clinicians to choose between invasive management, which means oncologic resection, and conservative management. Preoperatively predicting the aggressiveness of NF-pNETs could guide clinicians to make individualized management decisions.

Conference:

Presenting Author: Shen X

Authors: Shen X, Jiang T, Mohammad Z, Wang X, Xie Z,

Keywords: aggressiveness, pancreatic neuroendocrine tumor, computed tomography, nomogram,

#3608 Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in non-functional pancreatic neuroendocrine tumors

Introduction: Death domain-associated protein (DAXX) and/or α-thalassemia/mental retardation X-linked (ATRX) chromatin remodelling genes mutations and alternative lengthening of telomeres (ALT) activation are associated with more aggressive behaviour of non-functional pancreatic neuroendocrine tumors (NF-pNETs).

Conference:

Presenting Author:

Authors: Mastrosimini M, Manfrin E, Remo A, de Bellis M, Pedron S,

Keywords: pancreatic tumor, ALT, FISH, immunohistochemistry,