Abstract Library

Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.

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#4175 Immunohistochemical profiling of lung carcinoid subtypes and marker comparison of matched primary and metastatic tumors

Introduction: Multi-omic studies have identified three lung carcinoid (LC) subtypes (A1, A2, B) with unique gene expression for OTP, ASCL1 & HNF1a.

Conference:

Presenting Author: Leunissen D

Authors: Leunissen D, Moonen L, von der Thüsen J, den Bakker M, Hillen L,

Keywords: lung carcinoid, TTF1, S100, metastatic disease,

#3854 Protein validation of multi-omic classified pulmonary carcinoid – Identification of unique clinical subtypes and potential therapeutic vulnerability

Introduction: Multi-omic studies have identified three pulmonary carcinoid (PC) subtypes (A1, A2, B) with unique expression for OTP, ASCL1 & HNF1a.

Conference:

Presenting Author: Derks J

Authors: Derks J, Moonen L, Leunissen D, von der Thüsen J, den Bakker M,

Keywords: lung carcinoid, biomarker, molecular profile, OTP, ASCL1, HNF1a,

#3462 Development and verification of a new monoclonal OTP specific antibody for pulmonary carcinoid diagnostics

Introduction: Histology-based grading of pulmonary carcinoids (PC) is problematic and subject to high interobserver variation. Orthopedia homeobox (OTP) has shown to be an excellent prognostic marker for PCs, also indicated by the WHO. However, absence of a reliable routinely applicable monoclonal OTP antibody (mAb) hampers implementation in routine diagnostics.

Conference:

Presenting Author: Speel E

Authors: Moonen L, Derks J, Lap L, Marijnissen B, van den Bosch T,

Keywords: Orthopedia Homeobox, pulmonary carcinoid, monoclonal antibody, clinical diagnostics,

#3395 Changes in DNA methylation are associated with differential Orthopedia Homeobox (OTP) expression in pulmonary carcinoids

Introduction: Limited number of tumor types have been examined for Orthopedia Homeobox (OTP) expression. In pulmonary carcinoids, loss of expression is a strong indicator of poor prognosis.

Conference:

Presenting Author: Moonen L

Authors: Moonen L, Mangiante L, Leunissen D, Gabriel A, Hillen L,

Keywords: Pulmonary, neuroendocrine, carcinoid, DNA methylation, Orthopedia Homeobox,

#3228 Sensitivity of 68Ga-DOTATATE PET in detecting primary tumor and nodal metastases in surgically resected lung carcinoids

Introduction: 68Ga-DOTATATE positron emission tomography (PET) is increasingly employed in staging of lung carcinoids prior to surgery.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Rakshit S

Authors: Rakshit S, Lee K, Kendi A, Wigle D, Leventakos K,

Keywords: DOTATATE PET, staging, carcinoid,