Abstract Library
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#4521 [18F]FDG (FDG) PET/CT metrics as prognostic biomarkers in the AGITG NABNEC trial
Introduction: NABNEC was a prospective phase II trial investigating carboplatin/nab-paclitaxel in patients with advanced Grade 3 NENs (NCT02215447).
Conference:
Presenting Author: Kong G
Authors: Kong G, Ayati N, Brown C, Siu D, Mak W,
Keywords: Prognostic marker, prospective trial, chemotherapy, PET imaging, FDG, metabolic tumour volume, suv,
Introduction: The utility of fluorodeoxyglucose positron emission tomography (FDG-PET) in the evaluation of lung neuroendocrine tumours (L-NETs) remains debated.
Conference:
Presenting Author:
Authors: Twito O, Muzykovskaia E, Frenkel M,
Keywords: lung neuroendocrine tumour, imaging, FDG-PET,
Introduction: Accurate contouring for [68Ga]DOTATATE PET in NEN is challenging due to differing physiological uptake for the liver, spleen and other organs. This poses a significant problem for absolute thresholding algorithms using a single threshold, even if the threshold is based on liver uptake (as suggested for FDG PET by PERCIST). Improved contouring of PET to measure [68Ga]DOTATATE-avid tumour volume could help clinical translation of this potential biomarker.
Conference:
Presenting Author: Chan D
Authors: Chan D, Mokhtar S, Bernard E, Diakos C, Sabahi Z,
Keywords: prognostic biomarker, PET imaging, [68Ga]DOTATATE, Total Lesion Volume,
Introduction: 18F-FDG PET/CT avidity predicts for higher histological grade and worse prognosis in patients with NEN. However, there is less evidence regarding the role of FDG-avid tumor volume in predicting prognosis.
Conference:
Presenting Author:
Authors: Chan D, Hayes A, Karfis I, Conner A, Mileva M,
Keywords: prognostic biomarker, PET imaging, 18F-FDG, metabolic tumor volume,
Introduction: [18F]AlF-NOTA-octreotide ([18F]AlF-OC) is a promising alternative for [68Ga]Ga-DOTA-somatostatin analogues (SSAs) in PET imaging of the somatostatin receptor (SST).
Conference:
Presenting Author: Leupe H
Authors: Leupe H, Vandamme T, van den Broeck B, Lybaert W, Dekervel J,
Keywords: Neuroendocrine tumor, nuclear medicine, PET imaging, somatostatin receptor, [68Ga]Ga-DOTA-SSA, [18F]AlF-NOTA-octreotide,