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#2297 Merkel Cell Carcinomas in New Zealand: Virus or Ultra Violet?
Introduction: Merkel Cell Carcinoma (MCC) is a rare Neuroendocrine skin tumour. MCC behavior is more aggressive than the more common Melanoma, with treatments often restricted to surgery or radiotherapy, although immunotherapy holds promise overseas. In 2008, a USA study identified an oncogenic polyomavirus (MCPyV) present in eight of ten tested MCC tumours. Studies from across Europe and the USA confirmed MCPyV presence in ~80% of all MCCs. However, a cohort from Australia found a rate of just 24%, suggesting an alternative mechanism; ultra violet (UV) exposure was suspected and later confirmed using genomic mutational signature analysis. Are these are two separate diseases, requiring different clinical management strategies for best patient outcomes?
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Robb T
Authors: Robb T, Woodhouse B, Parker K, Miller R, Hayward G,
Keywords: merkel, ddPCR, diagnostics, genomics,
Introduction: MCC is a rare and aggressive skin cancer with a neuroendocrine phenotype.Association between MCC and Polyomavirus is known.PD-1 and PD-L1 have recently become key players in the therapeutic landscape.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Birocco N
Authors: Mecca C, Maletta F, Caliendo V, Birocco N, Metovic J,
Keywords: merkel cell carcinoma, microenvironment, polyomavirus,
Introduction: MCC is a rare and aggressive cutaneous neuroendocrine cancer linked to exposure to the Merkel Polyomavirus (MCPyV). Cisplatin and VP16 chemo may be an effective treatment for metastatic MCC, but responses are often transient. The blockade of programmed death 1 (PD-1) immune inhibitory pathway by avelumab, an anti-PD-L1 checkpoint inhibitor, is being investigated in solid neoplasms. This strategy can also be of interest in MCC because these tumors often express PD-L1
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Pusceddu S
Authors: Femia D, Prinzi N, Vernieri C, Lo Russo G, Concas L,
Keywords: Merkel cell carcinoma, Avelumab,
Introduction: Merkel cell carcinoma of lymph node without primary tumour (MCCNWP) is a rare tumour which can be misinterpreted as lymph node metastasis (LNM) from a high-grade neuroendocrine carcinoma (NEC) on histological examination. However, this distinction is crucial for therapeutic management.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: KERVARREC T
Authors: Kervarrec T, Samimi M, Beby-Defaux A, Touze A, Guyetant S,
Keywords: Merkel cell carcinoma, lymph node, MCPyV,
Introduction: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that is often associated with Merkel cell polyomavirus (MCPyV) infection. MCPyV expression and its relationship with clinical features and prognosis in MCC remain unclear.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author:
Authors: Delektorskaya V, Orlova K, Smirnova E, Demidov L,
Keywords: merkel cell carcinoma, merkel cell polyomavirus, immunohistochemistry, prognosis,