Abstract Library

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ENETS Abstract Search

#2205 Analysis of MET and RET Expression in Patients with Pancreatic Neuroendocrine Tumors Receiving Everolimus

Introduction: Target therapy has improved the outcome of neuroendocrine tumors (NETs), but little is known about the strategies to overcome the acquired resistance. MET is considered one of the putative mechanisms of resistance. RET is also rearranged in some other endocrine tumors (like thyroid).

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Cella C, Barberis M, Spad F, Pisa E, Laffi A,

Keywords: Everolimus, MET, RET,

#1892 Feasibility and Implication of Routine NGS Analysis in Neuroendocrine Carcinomas

Introduction: Neuroendocrine carcinomas (NECs) may arise from any organ system, exhibit various degree of differentiation and have Ki67 indices ranging from 21-100%. After first-line platin based chemotherapy, no standard treatment exists.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Knigge U, Federspiel B, Andreassen M, Kjær A, Langer S,

Keywords: neuroendocrine, neuroendocrine neoplasms, neuroendocrine carcinoma, ngs, genes, mutation, ki67, tp53, kras, braf, pik3a, pten,

#1775 Potential Therapeutic Targets for Gastric Poorly Differentiated Neuroendocrine Carcinoma

Introduction: Gastric poorly differentiated neuroendocrine carcinoma (G-PDNEC) is rare and aggressive. Patients often present with distant metastases at initial diagnosis.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: JI Y

Authors: Ji Y, Xie Y, Chen K, Zeng H, Sun Y,

Keywords: gastric, neuroendocrine carcinoma, mTOR pathway, SSTR, targeted therapies,

#1167 Cowden Syndrome and Concomitant Pulmonary Neuroendocrine Tumor: A Presentation of Two Cases

Introduction: Cowden Syndrome is a multiorgan disorder with germline mutations in the tumor suppressor gene PTEN leading to dysfunctional cell growth and risk of neoplasms in e.g. breast and thyroid, but no association with NET has been described.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Ringholm L

Authors: Ringholm L, Langer S, I Dali C, Petersen R, Rasmussen A,

Keywords: Cowden Syndrome, pulmonary NET,

#1119 Gly388Arg FGFR4 Polymorphysm is Not Predictive of Everolimus Efficacy in Gastrointestinal Well Differentiated Neuroendocrine Tumors (NET)

Introduction: Preclinical data suggest that single nucleotide polymorphism substituting an arginine (R) for glycine (G) in codon 388 of the FGFR4 transmembrane domain may increase proliferation of xenografted neuroendocrine cell lines and decrease their sensitivity to everolimus by modulating STAT3 signaling and the mTOR pathway.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Cros J

Authors: Cros J, Moati E, Raffenne J, Hentic O, Svrcek M,

Keywords: N,