Abstract Library

#4625 Efficacy and safety of capecitabine-temozolomide (CAPTEM) regimen in patients with neuroendocrine neoplasms – A systematic review and experience from NETwerk, a Belgian ENETS Center of Excellence

Introduction: Current treatment guidelines remain inconclusive due to scarcity of data regarding the optimal systemic treatment for metastatic gastroenteropancreatic (GEP) neuroendocrine tumours (NET) grade 3 and aggressive GEP-NET grade 2. Similarly, for metastatic pulmonary typical (TC) and atypical carcinoids (AC), the indication for chemotherapy is unclear. Recent evidence highlights a promising role for CAPTEM, combining temozolomide (TEM) with capecitabine (CAP), showing encouraging antitumoural activity and safety profiles for these indications.

Conference:

Presenting Author: Chhajlani S

Authors: Chhajlani S, Lambrechts C, Islam O, de Weerdt C, Verbruggen L,

Keywords: capecitabine, temozolomide, CAPTEM, GEP-NET, pulmonary NEN, safety, efficacy, systematic review,

#4437 Pancreatic metastases in neuroendocrine neoplasia: A systematic review

Introduction: Neuroendocrine neoplasias (NENs) are a heterogeneous group of neoplasms that often metastasise to distant organs, with the liver and bones as common targets. However, metastases to the pancreas are uncommon, accounting for 2–5% of pancreatic malignancies.

Conference:

Presenting Author:

Authors: Rinzivillo M, Romano E, Dell' Unto E, Marasco M, Panzuto F,

Keywords: pancreatic metastasis, 68Gallium-PET, incidence,

#4118 Adverse events after endoscopic ultrasound-guided fine-needle aspiration and fine-needle biopsy in pancreatic neuroendocrine tumors: A systematic review

Introduction: Pathological analysis of pancreatic neuroendocrine tumors (pNET) is essential for predicting tumor behaviour and patient management. Although endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the established practice for retrieving tissue, fine-needle biopsy (EUS-FNB) offers possibilities for additional analyses including tumor grading. This systematic review provides a comprehensive evaluation of EUS-FNA and EUS-FNB-related adverse events in pNET.

Conference:

Presenting Author: Chen J

Authors: Chen J, Verschuur A, Abdelmonem A, Dreijerink K, Engelsman A,

Keywords: pancreatic neuroendocrine tumor, EUS-FNA, EUS-FNB, adverse events, systematic review,

#4004 Prevalence of depressive and anxiety symptoms and disorders in neuroendocrine neoplasms: A systematic review and meta-analysis

Introduction: Neuroendocrine neoplasms (NENs) represent a heterogeneous and rare category of tumors. Currently, the prevalence of anxiety and depression among NEN population remains unknown.

Conference:

Presenting Author: Chen X

Authors: Chen X, Lu C, Yu F, Cheng Z, Chen Y,

Keywords: neuroendocrine neoplasm, anxiety, depression, systematic review,

#3968 A systematic review of hepatic transplantation for neuroendocrine liver metastases – Focus on long-term outcomes

Introduction: Neuroendocrine neoplasms frequently metastasise to the liver. Neuroendocrine liver metastases (NELM) may be treated with a broad range of therapeutic options - liver transplantation (LT) being an uncommon, potentially promising, but controversially debated approach.

Conference:

Presenting Author: Clift A

Authors: Palaniappan V, Lei C, Frilling A, Clift A,

Keywords: liver metastases, transplantation, systematic review,