Abstract Library

#4667 Clinical outcomes in patients with typical (TC) and atypical bronchial carcinoids (AC): A 15-year retrospective study from an ENETS Center of Excellence

Introduction: Bronchial neuroendocrine neoplasms (NENs) can be subdivided into TCs, ACs and neuroendocrine carcinomas (NECs). Although a few studies have explored treatment approaches and oncological outcomes, most focus on surgical cohorts, small sample sizes, or mixed groups including TC, AC, and NECs. Real-life cohort data are lacking.

Conference:

Presenting Author: Clement D

Authors: Correia J, Sarker D, Dolly S, Frydman A, Srirajaskanthan R,

Keywords: bronchial carcinoid, treatment pattern, recurrence-free survival, overall survival,

#4229 Bone health in neuroendocrine neoplasms

Introduction: Neuroendocrine neoplasms (NENs) are a heterogeneous group of rare neoplasms, classified according to localization of the primary tumor, differentiation and grading. The effect of localized or advanced NENs and systemic therapies on bone and muscle health is still controversial.

Conference:

Presenting Author:

Authors: Casabella A, Veresani A, Boschetti M, Sulli A, Hasballa I,

Keywords: Bone health, neuroendocrine neoplasm, TBS, RSMI, T-Score,

#3812 Validation of NEP-D score as a prognostic index in bronchial carcinoid tumors

Introduction: The development of prognostic scores able to classify patients with Bronchial Carcinoid (BC) according to clinical outcomes may help guide treatment selection. The NEP- score was found to be useful to stratify survival probability in patients with well-differentiated neuroendocrine neoplasms (NENs). According to multiple factors (age, primary tumor site, presence of metastasis, Ki-67, presence of functioning status and prior surgical removal of the primary tumor) NEP- score stratifies patients into different risk groups. The NEP-score at diagnosis (NEP-D score) is a derived score that could be calculated at diagnosis and does not consider the appearance of new metastases during follow-up.

Conference:

Presenting Author:

Authors: Medici M, Gagliardi I, Zanata I, Borges de Souza P, Ambrosio M,

Keywords: Bronchial Carcinoid, Neuroendocrine neoplasm, NEP-Score, Prognosis, Survival,

#3715 Finding the frequency of bronchial carcinoid tumors associated with neuroendocrine syndrome

Introduction: Pulmonary carcinoid tumors are part of bronchopulmonary neuroendocrine neoplasms (bpNETs) along with large and small cell pulmonary carcinoma. They are capable of producing a variety of peptides and biological active hormones such as serotonin, histamine, bombesin thus leading to several endocrine syndromes.

Conference:

Presenting Author:

Authors: Fatima A,

Keywords: bronchial carcinoid, pulmonary carcinoma, carcinoid syndrome,

#3320 TGF-β increase caspase activation and migration in typical bronchial carcinoids

Introduction: Typical bronchial carcinoids (TBC) are well-differentiated neuroendocrine neoplasms (NEN) whose management can still be very challenging due to reduced sensitivity to therapy. Previous studies have reported TGF-β’s ability to activate mTOR pathway and induce epithelial to mesenchymal transition (EMT). Moreover, preliminary results show an overexpression of TGF-β signalling and caspase activation in TBC.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Gagliardi I

Authors: Borges de Souza P, Gagliardi I, Martelli M, Zatelli M,

Keywords: bronchial carcinoid, TGF-β signalling, mTOR, EMT,