Abstract Library

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ENETS Abstract Search

#1551 Establishment and Characterization of Three GEP-NEC Cell Lines for In Vitro and In Vivo Studies

Introduction: To date chemotherapeutic concepts applying cisplatin/etoposide for the treatment of highly aggressive GEP-NEC do not provide convincing results. Thus, there is an urgent need for NEC cell line models that provide a reliable experimental system in identifying novel therapeutic targets.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Krieg A

Authors: Krieg A, Riemer J, Dizdar L, Mersch S, Anlauf M,

Keywords: GEP-NEC,

#1180 A Novel Human Cell Line from Familial Medullary Thyroid Carcinoma

Introduction: Cell lines from hereditary medullary thyroid carcinomas (MTC) are very rare, therefore, there is a substantial need to establish new cell lines. Here, we present a novel familial MTC (FMTC) cell line, designated SCHWE.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Pfragner R, Schwach G, Hoeger H, Ghaffari Tabrizi-Wizsy N, Tam Amersdorfer C,

Keywords: novel MTC cell line, familial MTC, xenografts,

#967 Correlation Between Genomic Imbalances, Cell Proliferation and Tumor Size in Sporadic Pancreatic Neuroendocrine Tumors

Introduction: The pathogenesis of sporadic pancreatic neuroendocrine tumors (pNET) is poorly understood.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Haugvik S

Authors: Haugvik S, Gorunova L, Haugom L, Eng Eibak A, Gladhaug I,

Keywords: pNET, genomic imbalances, CGH, karyotyping,

#856 DAXX and ATRX Loss Defines Chromosomal Instability and Poor Outcome in Pancreatic NET

Introduction: Chromosomal Instability (CIN) has been reported in pancreatic neuroendocrine tumors (pNETs) with poor outcome. However, no specific genetic background has been associated with CIN. Whole exome sequencing revealed mutations in DAXX (Death domain associated protein gene) and ATRX (ATR-X gene) in 40% of pNETs. DAXX and ATRX mutations in pNETs are associated with Alternative Lengthening of Telomeres (ALT) activation.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Marinoni I, Schmitt A, Vassella E, Dettmer M, Rudolph T,

Keywords: pNET, Daxx, Atrx, ALT, CIN,

#646 Immunohistochemical (IHC) and Cytogenetic Approach for Improving Diagnosis and Therapy of Ewing Sarcoma (ES)/pPNET Arising in the Ileocecal Region

Introduction: ES/pPNET primary to the ileocecal region (IpPNET) have been rarely reported on and show close similarities in histology and clinical presentation with small round blue cell tumors. The EWS gene is fused to four members of the ETS family.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: MILIONE M

Authors: Milione M, Gasparini P, Pusceddu S, Damato A, Pellegrinelli A,

Keywords: EWS, pPnet, FEV,