Abstract Library

#4618 The exceptionally rare phenomenon of well-differentiated colon neuroendocrine tumours

Introduction: Colonic neuroendocrine tumours (NETs), excluding rectal NETs, are often described as relatively common and aggressive, with inferior median survival compared to other gastrointestinal (GI) primary sites. However, epidemiological databases may conflate well-differentiated NETs with poorly differentiated NECs, leading to unclear data on prevalence, clinical behaviour, and prognosis of well-differentiated colonic NETs.

Conference:

Presenting Author: Al-Toubah T

Authors: Al-Toubah T, Strosberg J,

Keywords: colon, neuroendocrine tumour, caecum, sigmoid, neuroendocrine neoplasm,

#4056 High expression of ADAM15 in non-functional pancreatic neuroendocrine tumors is associated with high-density tumor-infiltrating neutrophils and predicts poor outcome

Introduction: Non-functional pancreatic neuroendocrine tumors (NF-PanNETs) displayed heterogeneous prognoses. Copy number variations (CNVs) of ADAM15 significantly increased in patients who underwent postoperative early recurrence. ADAM15 (a disintegrin and metalloproteinase 15) has been identified as a key molecule in progression and metastasis of many tumors, regulating immune infiltration. However, correlation between ADAM15 and NF-PanNETs remains unknown.

Conference:

Presenting Author:

Authors: Tang L, Ying Y, Peng M, Wang Y, Lou W,

Keywords: pancreatic neuroendocrine tumor, recurrence, metastasis, ADAM15, tumor-infiltrating neutrophils,

#3680 18F-FMISO PET in metastatic neuroendocrine neoplasms – A pilot study

Introduction: The phenomenon of peripheral 68Ga-DOTATATE avidity without central avidity (a so-called “donut") has been observed in neuroendocrine neoplasm (NEN) lesions. There has been speculation as to whether this region of non-avidity reflects hypoxia, de-differentiated disease or other causes. The presence of hypoxia has significant prognostic and therapeutic implications, and was evaluated in these lesions using 18F-FMISO PET/CT.

Conference:

Presenting Author: Chan D

Authors: Chan D, Conner A, Pavlakis N, Bailey E, Aslani A,

Keywords: hypoxia, 18F-FMISO, 68Ga-DOTATATE, PET/CT, biomarker,

#3677 Myelophthisis as an end-stage outcome of rare metastases in neuroendocrine tumors – A dual case report

Introduction: Intra-abdominal Neuroendocrine Tumors (NETs) usually metastasize to regional lymph nodes, liver, and bone. Myelophthisis (MPT) is the destruction of the medullary microenvironment due to the tumoral invasion of the trabecular space, altering normal hematopoiesis; it’s frequently caused by metastasis of breast, prostate, and lung adenocarcinomas, and neuroblastoma. MPT due to NET is an unrecognized phenomenon with few cases reported, almost exclusively in poorly differentiated NETs.

Conference:

Presenting Author:

Authors: González Devia D, Aldana-Gómez L, Segovia Gómez J, Ortiz-Santacruz C, Mejía-Arango M,

Keywords: Neuroendocrine Tumor, Myelophthisis, Colon tumor, Prostate tumor, End-stage,

#3445 The epidemiology of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in the North-East of England and a systematic review of literature

Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare, slow-growing malignancies with unknown aetiology and an increasing incidence was observed globally. With limited research on GEP-NET epidemiology, the reasons behind incidence disparities across countries remain unclear. Whether this increase was a true phenomenon or confounded by factors including diagnostic advancement, environment, and classification evolution needs further enquiry.

Conference:

Presenting Author:

Authors: Chu G, Robinson S, Etherson K, McNally R,

Keywords: Gastroenteropancreatic neuroendocrine tumor, Epidemiology, Incidence,