Abstract Library

#3910 Integrative molecular analysis of lung neuroendocrine neoplasms with different Ki-67 indices identifies a molecular transition group between low- and high-grade neoplasms

Introduction: In the 2021 World Health Organization (WHO) classification of lung cancers, lung neuroendocrine neoplasms (LNENs) are classified as low-grade, intermediate-grade and high-grade based on mitotic count but not Ki-67 index, as for GEP-NENs.

Conference:

Presenting Author:

Authors: Simbolo M, Centonze G, Ali G, Grillo F, Sabella G,

Keywords: lung neuroendocrine tumor, NET grade 3, next generation sequencing, transcriptomics,

#3243 The major impact of proGRP monitoring in advanced atypical lung carcinoid: A case report

Introduction: Atypical lung carcinoids (aLC) are more aggressive than typical carcinoids, metastasizing more commonly to distant sites, and require vigilant follow-up. However, the surveillance is often hampered by the non-informative Chromogranin A (CgA) levels.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Oleinikov K, Ben-Haim S, Atlan K, Nisman B, Bloom A,

Keywords: pro-GRP, lung carcinoids, biomarker,

#3210 “Lung side & sites”, the importance of localization and prognostic implications in pulmonary neuroendocrine tumors: An Italian-Spanish multicentric study of 139 cases

Introduction: Well-differentiated neuroendocrine lung tumors (Lung NET) are classified as typical (TC) and atypical (AC) carcinoids, based on mitotic counts and the presence of necrosis. However, a prognostic role for primary tumor localization (central vs peripheral and right vs left) has not been established yet.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: La Salvia A, Persano I, Verrico M, Bassi M, Modica R,

Keywords: lung neuroendocrine tumor, primary tumor's side (left versus right), tumor site (peripheral versus central), prognostic factors, survival,

#3032 Lung Side and Site: The Importance of Location and the Prognostic Implication in Lung Neuroendocrine Tumors

Introduction: Lung neuroendocrine tumors (NET) are classified as typical (TC) and atypical carcinoids (AT), according to their mitotic count and the presence of necrosis. However, a role for tumor side (right vs left) and location (central vs peripheric) has not been established so far.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: La Salvia A

Authors: La Salvia A, Trevisi E, Brizzi M, Espinosa Olarte P, Enguita A,

Keywords: Lung neuroendocrine tumors, tumor side (left versus right), tumor site (peripheric versus central), prognostic factors, survival,

#2983 Differential TGF-β Signalling in Typical and Atypical Bronchial Carcinoids

Introduction: Typical and atypical bronchial carcinoids (TBC and ABC) are well-differentiated neuroendocrine neoplasms (NEN). Metastatic BC having low to moderate mitotic count may still be treated with somatostatin analogues and mTOR inhibitors; however, TBC and ABC have been reported to respond very differently to therapy and an effective treatment algorithm is still lacking. TGF-β is known for its ability to activate mTOR pathway and induce epithelial mesenchymal transition, affecting cell pathophysiological capabilities such as proliferation, migration and tissue invasiveness.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Borges de Souza P

Authors: Borges de Souza P, Tagliatti V, Capobianco S, Ambrosio M, Chinnici S,

Keywords: Neuroendocrine neoplasms, bronchial carcinoids, TGF-β,