Abstract Library

#4326 An evaluation of the methodological quality of published guidelines for the surgical treatment of pulmonary carcinoids

Introduction: Leading societies have established guidelines that vary significantly regarding recommendations for surgical management of pulmonary carcinoids (PC).

Conference:

Presenting Author: Bertolaccini L

Authors: Bertolaccini L, Bardoni C, Caffarena G, Chiari M, Diotti C,

Keywords: Neuroendocrine, lung cancer, surgery, AGREE 2, methodology, guidelines,

#4135 ALK-targeted therapy in atypical carcinoid of the lung: A case report

Introduction: Atypical pulmonary carcinoids with anaplastic lymphoma kinase (ALK) rearrangement are extremely rare. The effectiveness of ALK-targeted therapy in such individuals remains unclear. This article reports a patient diagnosed with ALK-positive metastatic atypical carcinoid (AC) of the lung, who achieved tumor remission following first-line treatment with alectinib.

Conference:

Presenting Author:

Authors: Sun Y, Tan H, Ying J, Jiang L, Chi Y,

Keywords: neuroendocrine tumor of the lung, anaplastic lymphoma kinase, alectinib, atypical carcinoid,

#3889 Patterns of recurrence in patients with resected pulmonary carcinoid – A Dutch nationwide study

Introduction: In patients (pts) with resected pulmonary carcinoids (PC), recurrence of disease may occur up to 10 years after surgery, but the exact incidence remains unknown.

Conference:

Presenting Author: Moonen L

Authors: Moonen L, Derks J, Hillen L, den Bakker M, von der Thüsen J,

Keywords: Pulmonary carcinoid, recurrence, surgery, screening, nationwide registry,

#3867 Radiological follow-up (FU) in resected pulmonary typical carcinoids (pTC) – Do the benefits outweigh the risks?

Introduction: Primary resection is treatment of choice of pulmonary carcinoids (PC) and recurrences occur ~7% of TC and ~35% of atypical carcinoid (AC). Because of a risk of late recurrence, even in TC, long-term radiological FU is generally advised. As PC are frequent in relatively young pts, there is a risk of late radiation-induced cancer.

Conference:

Presenting Author: Heijboer F

Authors: Heijboer F, Mulders T, van Straten M, Moonen L, Speel E,

Keywords: pulmonary carcinoid, typical carcinoid, atypical carcinoid, primary resection, follow-up, ct scan,

#3845 The lungNENomics project – A comprehensive multidisciplinary characterisation of pulmonary carcinoids

Introduction: Lung neuroendocrine tumors (LNETs) are subdivided into low-grade (typical) and intermediate-grade (atypical) carcinoids, at higher risk of developing metastases. We have previously identified 3 LNETs molecular groups with different prognoses, as well as “supra-carcinoids” with molecular profiles of higher-grade neuroendocrine carcinomas. Despite promising results, there is still no consensus on their differential diagnosis and treatment and little is known about how some tumors evolve toward more aggressive phenotypes.

Conference:

Presenting Author:

Authors: Foll M, Sexton-Oates A, Mathian E, Alcala N, Mangiante L,

Keywords: lung carcinoid, deep learning, genomic, evolution, multi-omics, spatial analyses,