#4441
Gastric neuroendocrine neoplasms in younger patients: A retrospective single-centre study
Introduction:
Gastric neuroendocrine neoplasms (gNENs) are rare neoplasms arising from stomach enterochromaffin-like (ECL) cells. Type I gNENs are the most common type, typically indolent and arising in the context of chronic atrophic gastritis (CAG). While type I gNENs are generally diagnosed in pts over 50, their occurrence in younger pts raises concern about the onset of CAG-related complications at an earlier age, potentially affecting tumour growth and clinical outcomes. Young-oriented studies on type I gNETs are still lacking in literature.
Conference:
Presenting Author:
Authors:
Romano E,
Rinzivillo M,
Marasco M,
Dell' Unto E,
Esposito G,
Keywords:
Gastric neuroendocrine neoplasm,
Young adults,
Chronic Atrophic Gastritis,
#406
YF476, a Gastrin Receptor Antagonist, Causes Regression of Tumors and Normalizes Serum Chromogranin A in Patients with Type 1 Gastric Carcinoids
Introduction:
Chronic atrophic gastritis (CAG) results in achlorhydria, hypergastrinemia and, in some patients, gastric carcinoids (type 1 GCs). Type 1 GCs may become malignant and metastasize. Current treatments of type 1 GCs, such as polypectomy, somatostatin analogues and antrectomy, have their disadvantages. YF476 – a potent, selective, orally active and well-tolerated gastrin receptor antagonist in pre-clinical studies – prevented, as well as reduced, the number and size of gastric carcinoids and carcinomas in rodent models.
Conference:
9th Annual ENETSConcerence (2012)
Presenting Author:
Authors:
Fossmark R,
Sørdal �,
Jianu C,
Qvigstad G,
Boyce M,
Keywords:
gastric carcinoids,
gastrin,
chromogranin A,
#295
Unusual Behavior of Gastric Carcinoid Type 1
Introduction:
Gastric carcinoids (GC) are rare tumors of the stomach. GC type 1 are associated with chronic atrophic gastritis (CAG) and are the most benign type, having low metastatic potential.
Conference:
8th Annual ENETSConcerence (2011)
Presenting Author:
Authors:
Spampatti M,
Massironi S,
Rossi R,
Conte D,
Ciafardini C,
Keywords:
gastric carcinoid type 1,
metastatic disease,
well-differentiated endocrine tumors,
Ki-67index,
