Abstract Library

#3845 The lungNENomics project – A comprehensive multidisciplinary characterisation of pulmonary carcinoids

Introduction: Lung neuroendocrine tumors (LNETs) are subdivided into low-grade (typical) and intermediate-grade (atypical) carcinoids, at higher risk of developing metastases. We have previously identified 3 LNETs molecular groups with different prognoses, as well as “supra-carcinoids” with molecular profiles of higher-grade neuroendocrine carcinomas. Despite promising results, there is still no consensus on their differential diagnosis and treatment and little is known about how some tumors evolve toward more aggressive phenotypes.

Conference:

Presenting Author:

Authors: Foll M, Sexton-Oates A, Mathian E, Alcala N, Mangiante L,

Keywords: lung carcinoid, deep learning, genomic, evolution, multi-omics, spatial analyses,

#3780 Evaluation of tumor tissue miRNAs for assessing the grade of pancreatic neuroendocrine tumors from FFPE samples

Introduction: Our research aims were to determine whether the human tissue microRNAs miR-21, miR-96, miR-130b and miR-210 are of use in the differential diagnosis of grade 1 and grade 2 pancreatic neuroendocrine tumors (PNET).

Conference:

Presenting Author: Nyirő G

Authors: Nyirő G, Szeredás B, Moloney C, Turai P, Vékony B,

Keywords: PNET, FFPE, RT-QPCR, miR-21, miR-96, miR-130b, miR-210, miRNA, Grade 1, Grade 2,

#3733 New insights on the clinical role of Ki-67 and spindle cell and oncocytic histological variants in lung carcinoid tumors

Introduction: WHO classification defines lung carcinoid tumors (LCTs) as well-differentiated neuroendocrine neoplasms classified in typical (TC) and atypical carcinoids (AC). Morphologic factors and protein expression able to predict recurrence after surgical curative resection are little known. Ki-67 and spindle cell and oncocytic histological variants may impact on differential diagnosis, but their clinical relevance is much debated.

Conference:

Presenting Author: Milione M

Authors: Centonze G, Maisonneuve P, Grillo F, Prinzi N, Lagano V,

Keywords: lung carcinoid, Ki-67, spindle cell, oncocytic, Immunohistochemistry,

#3448 Differential diagnosis of diarrhoea in patients with neuroendocrine tumors

Introduction: Patients with neuroendocrine tumors (NETs) frequently experience diarrhoea that can impact their quality of life. Pancreatic enzyme insufficiency (PEI), bile acid diarrhoea (BAD) and small intestinal bacterial overgrowth (SIBO) are potential causes. There is a limited data on prevalence of these conditions in NETs.

Conference:

Presenting Author: Navaratnam J

Authors: Navaratnam J, Reed H, Sivananthan M, Rela A, Khan M,

Keywords: Neuroendocrine, Research, Diarrhoea, Quality of LIfe,

#3434 Retrospective study on 515 cases misdiagnosed as neuroendocrine neoplasms from a pathologic consultation center

Introduction: Recent progress in the diagnosis and classification of Neuroendocrine Neoplasms (NENs) is achieved. However, the histological morphology and immunohistochemistry of NENs overlap with other lesions, and the differential diagnosis in clinical practice faces many challenges.

Conference:

Presenting Author:

Authors: Huang D, Nu C, Sheng W,

Keywords: neuroendocrine neoplasm, misdiagnose, pathologic consultation,