Abstract Library

#4587 Exploring the splicing landscape to identify survival-related biomarkers in small intestine neuroendocrine neoplasms

Introduction: The study of small intestine neuroendocrine neoplasms (siNENs) is challenging due to their rarity and complexity. While transcriptomic subtypes have been identified, the mechanisms behind their progression are still unclear. The process of RNA splicing is often altered in cancer, and our group has described that such dysregulation is also present in various NENs.

Conference:

Presenting Author: Ibáñez Costa A

Authors: Ibáñez-Costa A, García Vioque V, Pedraza-Arévalo S, Hernando Cubero J, García A,

Keywords: small intestine neuroendocrine tumour, splicing, biomarker, survival, ki-67, RNA,

#4300 A retrospective comparison of preoperative characteristics and surgical outcomes in small intestine neuroendocrine neoplasms (SiNENs) and small intestine adenocarcinoma

Introduction: SiNENs are complex tumours with unique behaviour. Despite 30 years of progress, limited data and diagnostic challenges hinder understanding, complicating assessment of their biology and outcomes.

Conference:

Presenting Author: Zamparas A

Authors: Herzog T, Zamparas A, Uhl W, Strotmann J, Höhn P,

Keywords: small intestine NEN, small bowel adenocarcinoma, NET, Chromogranin A, 5-year follow-up, 10-year follow-up,

#4199 Unravelling the RNA landscape of small intestine neuroendocrine neoplasms applying transcriptomic and spliceosomic perspectives

Introduction: The study of small intestine neuroendocrine neoplasms (siNENs) transcriptomics represents a challenge due to their rarity, tissue availability, and heterogeneity. Recent studies identified different molecular subtypes, but there are still gaps in the molecular mechanisms driving siNEN progression.

Conference:

Presenting Author:

Authors: Ibáñez-Costa A, Pedraza-Arevalo S, Moreno-Montilla M, Hernando J, García A,

Keywords: small intestine neuroendocrine neoplasm, splicing, transcriptomics, biomarker,

#3479 Mesenteric fibrosis in SI-NEN is characterized by strong dysregulation of CXCL9, IL6, COMP and COL6A6 genes

Introduction: Small intestine neuroendocrine neoplasms (SI-NENs) are characterized by the development of desmoplastic mesenteric fibrosis (MF) in up to 50 % of cases. This can cause intestinal obstruction and ischemia, which is a significant clinical problem.

Conference:

Presenting Author:

Authors: Graf S, Keber C, Hattesohl A, Denkert C, Di Fazio P,

Keywords: si-nen, si-net, comp, col6a6, cxcl9, il6, mesenteric fibrosis, desmoplasia, desmoplastic reaction, tumor microenvironment, tme, tumor stroma interaction, next generation sequencing, ngs, htg edgeseq, gene expression analysis, rna,

#3457 Relevant prognostic factors in patients with stage IV small intestine neuroendocrine neoplasms

Introduction: There are only few, but controversial data on the prognostic role of upfront primary tumor resection and mesenteric lymph node dissection (PTR) in patients with stage IV small intestinal neuroendocrine neoplasia (SI-NEN).

Conference:

Presenting Author:

Authors: Maurer E, Heinzel-Gutenbrunner M, Rinke A, Rütz J, Figiel J,

Keywords: stage 4 small intestine neuroendocrine neoplasm, primary tumor resection, survival, peptide receptor radionuclide therapy,