Abstract Library

#4209 Transcriptomic and spliceosomic landscapes of pancreatic neuroendocrine tumors generated through Oxford Nanopore Technology sequencing

Introduction: Pancreatic Neuroendocrine tumors (PanNETs) are rare neoplasms with heterogenous nature, still poorly understood. Their low mutational burden has prompted to explore other molecular aspects, from epigenomics to transcriptomics. Increasing evidence indicates that transcriptomic changes, often derived from alterations in alternative splicing, can generate isoforms with oncogenic potential. In this context, long-read Oxford Nanopore Technology (ONT) has emerged as an ideal suited sequencing tool to deeply study transcriptomics and splicing variants.

Conference:

Presenting Author: Moreno Montilla M

Authors: Moreno Montilla M, Jones G, Jeffries A, Blazquez Encinas Rey R, Bamford R,

Keywords: Pancreatic Neuroendocrine Tumor, Oxford Nanopore Technology Sequencing, Transcriptomics, Splicing, Fusion Genes,

#4092 Liver transplantation for neuroendocrine tumor liver metastases: UK and Ireland’s pioneering pilot programme

Introduction: The incidence of neuroendocrine tumours (NETs) continues to rise. Liver metastases (LM) are commonly present at diagnosis. Liver transplantation (LT) has become an applicable treatment for a subset of these patients.

Conference:

Presenting Author: Rehman Z

Authors: Rehman Z, Ford S, Dasari B, Hughes S, El-Shafie M,

Keywords: metastases, transplant, liver, neuroendocrine,

#3718 Epidemiology of neuroendocrine neoplasms (NEN) in England 2012-2018 – Home location, incidence and survival including access to neuroendocrine centres of excellence (CoE)

Introduction: Many cancers have been associated with environmental factors but these remain unexplored for NEN. Travel to and from a CoE can be a significant burden to patients. There is evidence that this impacts on treatment outcomes and survival in other cancers.

Conference:

Presenting Author: Nwoguh C

Authors: Nwoguh C, Chandrakumaran K, White B, Russell B, Handford J,

Keywords: neuroendocrine, access to care, neuroendocrine neoplasm, incidence, geospatial, mapping, geographic, survival, environmental factors,

#3458 Post-PRRT imaging: Which scans to make and what to look for

Introduction: Post-PRRT imaging often focuses on dosimetry but seldom on its clinical utility.

Conference:

Presenting Author: Aalbersberg E

Authors: Aalbersberg E, Huizing D, Tesselaar M, Stokkel M, Versleijen M,

Keywords: PRRT,

#3339 Approval of a programme to perform 50 liver transplants for neuroendocrine tumor liver metastases in UK and Ireland affords significant opportunities for clinical study and research

Introduction: Liver transplantation for unresectable neuroendocrine tumor liver metastases [NET LM] remains a confusing and controversial area in managing NETs. Patients deemed most suitable for transplantation have good prognosis with standard therapy and best outcomes with transplantation are only achieved at highly experienced Centre(s).

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Shah T

Authors: Shah T, Gibbs P, Moore J, Venkataraman H, O'Toole D,

Keywords: neuroendocrine tumor, unresectable liver metastases, liver transplantation, Milan Criteria,