Abstract Library

#4584 Hepatic cytoreduction in advanced lung neuroendocrine neoplasms: A single institutional case series

Introduction: Role of hepatic cytoreductive surgery in well-differentiated gastroenteropancreatic neuroendocrine neoplasms (NENs) with liver metastases is well-described, however, its role in advanced lung NENs with liver metastases is unknown.

Conference:

Presenting Author: Grewal U

Authors: Grewal U, Patel R, Furqan M, Dillon J, Chandasekharan C,

Keywords: Lung neuroendocrine neoplasm, Hepatic cytoreductive surgery,

#4134 Assessment of the current and emerging criteria for the histopathological classification of lung neuroendocrine tumors in the lungNENomics project

Introduction: The lungNENomics project analysed 300 lung neuroendocrine tumors (NETs), of which 259 cases were pathologically reviewed by six expert pathologists.

Conference:

Presenting Author: Mathian E

Authors: Mathian E, Drouet Y, Sexton-Oates A, Papotti M, Pelosi G,

Keywords: Lung neuroendocrine neoplasm, Pathology, Deep-learning, Ki-67, PHH3,

#3910 Integrative molecular analysis of lung neuroendocrine neoplasms with different Ki-67 indices identifies a molecular transition group between low- and high-grade neoplasms

Introduction: In the 2021 World Health Organization (WHO) classification of lung cancers, lung neuroendocrine neoplasms (LNENs) are classified as low-grade, intermediate-grade and high-grade based on mitotic count but not Ki-67 index, as for GEP-NENs.

Conference:

Presenting Author:

Authors: Simbolo M, Centonze G, Ali G, Grillo F, Sabella G,

Keywords: lung neuroendocrine tumor, NET grade 3, next generation sequencing, transcriptomics,

#3847 RNA m6A methylation regulators in lung neuroendocrine neoplasms

Introduction: Lung carcinoids are commonly slow-proliferating neuroendocrine neoplasms (LungNENs) with a low mutational burden. Recent research has suggested a severe alteration in the profile of alternative splicing in LungNENs. In contrast, the role of emerging related systems like the genes regulating N6 methyladenosine (m6A), the most abundant internal modification of RNA, has been poorly explored in these rare tumors. We hypothesize that the expression profile of m6A-related genes could be altered in LungNENs in relation to their development.

Conference:

Presenting Author:

Authors: Ibáñez-Costa A, García Vioque V, Blázquez-Encinas R, Moreno Montilla M, Pedraza-Arévalo S,

Keywords: carcinoid, neuroendocrine tumor, lung, m6a, RNA, methylation,

#3568 Exploring the interplay between chromatin-remodeling genes and the regulation of alternative splicing and RNA biology in lung neuroendocrine neoplasms

Introduction: Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of rare tumors, but with a rising incidence in the last decades. The mutational landscape of LungNENs has been recently described; in contrast, other key regulatory mechanisms, particularly posttranscriptional processes linked to RNA regulation, remain largely unexplored.

Conference:

Presenting Author: Agraz-Doblas A

Authors: Agraz-Doblas A, Blázquez-Encinas R, Victor G, Alcala N, Sexton-Oates A,

Keywords: Lung NEN, Bioinformatics, Chromatin-remodeling, RNA, biomarker, mutations,