Abstract Library

#3733 New insights on the clinical role of Ki-67 and spindle cell and oncocytic histological variants in lung carcinoid tumors

Introduction: WHO classification defines lung carcinoid tumors (LCTs) as well-differentiated neuroendocrine neoplasms classified in typical (TC) and atypical carcinoids (AC). Morphologic factors and protein expression able to predict recurrence after surgical curative resection are little known. Ki-67 and spindle cell and oncocytic histological variants may impact on differential diagnosis, but their clinical relevance is much debated.

Conference:

Presenting Author: Milione M

Authors: Centonze G, Maisonneuve P, Grillo F, Prinzi N, Lagano V,

Keywords: lung carcinoid, Ki-67, spindle cell, oncocytic, Immunohistochemistry,

#3647 Autologous ECM-composed scaffolds and zebrafish PDXs for individualized theragnostic in rare neuroendocrine neoplasms

Introduction: Neuroendocrine neoplasms (NENs) are a subgroup of poorly characterized rare tumors with challenging management. Identification of clinically useful biomarkers for treatment tailoring is urgently needed.

Conference:

Presenting Author: Liverani C

Authors: Calabrese C, Miserocchi G, Vanni S, Mercatali L, de Vita A,

Keywords: NGS, zebrafish, autologous scaffold, molecular determinants,

#3581 Pancreatic neuroendocrine tumors (PanNETs) vascularization: From “micro” to “macro”

Introduction: Density of microvessels in pancreatic neuroendocrine tumors (PanNETs) changes according to their biological behaviour. Differently from other non-neuroendocrine cancers, a low microvessel density (L-MVD) is associated with higher disease aggressiveness and poorer prognosis.

Conference:

Presenting Author:

Authors: Battistella A, Andreasi V, Palumbo D, Tacelli M, de Cobelli F,

Keywords: pancreatic neuroendocrine tumor, microvessel density, imaging, computed tomography, endoscopic ultrasound, vascularization, enhancement, washout,

#3433 Role of [18 F]FDG PET/CT in the management of G1 gastro-entero-pancreatic neuroendocrine tumors

Introduction: Gastroenteropancreatic (GEP) neuroendocrine neoplasia (NET) is a heterogeneous disease. While 68-Ga PET is considered the gold standard in GEP-NETs, the role of [18F]FDG PET/CT is not well established, particularly in well-differentiated G1 NETs.

Conference:

Presenting Author: Magi L

Authors: Magi L, Prosperi D, Lamberti G, Marasco M, Ambrosini V,

Keywords: Neuroendocrine tumor, disease aggressiveness, prognosis, management, PET,

#3409 Ascl1 and OTP identify four prognostic groups among atypical carcinoids

Introduction: Atypical Carcinoids (AC) according World Health Organization guidelines are well differentiated Lung Neuroendocrine tumor with 2-10 mitoses/2 mm2 and/or with necrosis. Besides morphological differentiation no further tools in predicting AC clinical outcome are proposed.

Conference:

Presenting Author:

Authors: Centonze G, Maisonneuve P, Grillo F, Mangogna A, Prinzi N,

Keywords: Atypical Carcinoid, lung, ascl1, otp,