Abstract Library

#3058 Diagnosis and Assessment of Effectiveness of Surgical Resection of Small Bowel Neuroendocrine Tumours: The Roles of Circulating MicroRNAs

Introduction: MicroRNAs (miRNA) are small noncoding RNA molecules implicated in the pathophysiology of myriad neoplasms. Clinically useful biomarkers are needed in SB NET to ascertain disease aggressiveness, select treatment strategy, detect early recurrence and monitor response.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Clift A

Authors: Malczewska A, Frampton A, Prado M, Ameri S, Dabrowska A,

Keywords: neuroendocrine, small bowel, intestine, microRNA, biomarker,

#2001 The Anticancer Mechanism of Metformin in Pancreatic Neuroendocrine Tumor Cells

Introduction: Metformin, a widely used antidiabetic drug, has been reported to display potent anticancer properties in various types of cancers. In P-NETs, aryl hydrocarbon receptor-interacting protein (AIP) acts as a tumor suppressor and is up-regulated by the somatostatin analog octreotide.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Lania A

Authors: Vitali E, Piccini S, Boemi I, Brambilla T, Zerbi A,

Keywords: GEP-NET, Metformin, AIP,

#1673 Hsa-microRNA-202-3p Up-regulated in Type 1 Gastric Neuroendocrine Neoplasms

Introduction: Type 1 gastric neuroendocrine neoplasm (g-NENs) is a kind of rare malignant tumor. The molecular mechanism of this disease is unknown. MicroRNA (miRNA) plays important roles in the occurrence and development of tumors. At present, research about the role of miRNA in type 1 g-NENs is quite few.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Dou D

Authors: Dou D, Shi Y, Luo J, Tan H,

Keywords: type 1 g-NENs, miR-202-3p, up-regulated,

#756 Evaluation of VEGF, VEGFR 1-2-3 and Endocan/ESM-1 Expression in Gastroenteropancreatic Neuroendocrine Tumors and Correlation with Ki-67 Labeling and Prognosis

Introduction: Angiogenesis is recognized to play a critical role in progressive tumor growth and spreading and its inhibition is a valuable approach to cancer treatment. Markers of angiogenesis include assessment of microvessel density on tissue sections (often evaluated with antibodies against pan-endothelial antigens, such as CD34) and expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR 1-2-3). Endocan, also called endothelial cell specific molecule-1 (ESM-1), has been shown to be expressed by endothelial tumor cells and especially by tip cells during angiogenesis. Endocan is highly up-regulated by pro-angiogenic molecules, such as VEGF. Recently, Endocan has been identified to be one of the molecules involved in the switch from dormant to fast-growing tumors. Among endocrine tumors, Endocan expression has been evaluated only in pituitary adenomas: a positive association between endothelial Endocan expression and recurrence risk, tumor size, tumoral invasion and average mitosis count has been demonstrated. In contrast, there was no association between endothelial Endocan expression and the Ki-67 labeling index

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Lugli F, Iacovazzo D, Fusco A, Lanza P, Rindi G,

Keywords: endocan, angiogenesis, vegf,

#312 Evidence for the role of miR196a in regulating small intestinal neuroendocrine tumor proliferation and metastasis via HOX/AKT pathway activation

Introduction: MicroRNAs (miRNAs) regulate cell proliferation, differentiation, and apoptosis functioning as tumor suppressor genes but their role in NET proliferation and metastasis has not been fully evaluated.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Kidd M, Lawrence B, Alaimo D, Svejda B, Schimmack S,

Keywords: AKT, carcinoid, HOX, miRNA, metastasis, neuroendocrine tumor, proliferation, small intestine,