Abstract Library

#4174 Uncovering the genomic profiling of metastatic pheochromocytomas and paragangliomas: Leveraging plasma circulating tumor DNA for comprehensive genetic characterisation and monitoring

Introduction: Liquid biopsy, notably plasma circulating tumor DNA (ctDNA), is a non-invasive approach to elucidate the tumoral genomic profile from a blood sample. Pheochromocytomas and paragangliomas (PPGL) are often operated, characterized by quiet genomes and usually indolent tumor growth. However, challenges arise with metastatic tumors due to accessibility, catecholamine-related crises and surgery issues. Thus, molecular mechanisms transitioning from indolent to metastatic tumors are largely unexplored.

Conference:

Presenting Author:

Authors: Arenillas Lallana C, Moreno-Cárdenas A, Casteràs A, García-Álvarez A, Hernando J,

Keywords: liquid biopsy, ctDNA, metastasis, pheochromocytoma, paraganglioma, genomic targets,

#3872 Mixed neuroendocrine-non neuroendocrine neoplasms (MiNEN): Characterization of the genomic and pathological profile

Introduction: MiNENs is a novel defined rare entity, made up of two morphologically distinct neoplastic components; one neuroendocrine type (NEN), and the other one non-neuroendocrine type (nNEN). As available data are limited, the epidemiology and pathogenesis of MiNENs remain mostly unknown.

Conference:

Presenting Author:

Authors: Di Mauro A, Chianese U, Conte M, Benedetti R, Gerardo F,

Keywords: neuroendocrine, pathogenesis, mixed neuroendocrine, pathway, origin, molecular, molecular analysis, genomic profile,

#3686 Clinical and morphogenetic features of renal neuroendocrine tumors

Introduction: Renal neuroendocrine tumors (RenNETs) are extremely rare.

Conference:

Presenting Author: Kasajima A

Authors: Kasajima A, Pfarr N, von Werder A, Schwamborn K, Esposito I,

Keywords: Renal NET, WHO classification, Histology, immunohistochemistry, NGS,

#3619 The mutational, prognostic and therapeutic landscape of neuroendocrine neoplasms

Introduction: The rarity and heterogeneity of neuroendocrine neoplasms (NENs) limit the ability to develop precise therapies and novel prognostic biomarkers, thus a better understanding of their underlying molecular characteristics is critical.

Conference:

Presenting Author:

Authors: Liu M, Chen L, Wang Y, Lin Y, Luo Y,

Keywords: neuroendocrine neoplasm, genomic profile, immune signature, heterogeneity, prognostic signature, therapeutic target,

#2196 The Neuroendocrine Phenotype, Genomic Profile, and Therapeutic Sensitivity of GEPNET Cell Lines

Introduction: Patient tumour-derived cell lines have been widely used for studying the molecular mechanisms of tumours and their response to therapy. The establishment of cell lines from gastro-entero-pancreatic neuroendocrine tumours (GEPNETs) has proved difficult, but despite the challenges a limited amount of cell lines now exists.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Hofving T, Arvidsson Y, Almobarak B, Inge L, Pfragner R,

Keywords: neuroendocrine tumor, GEP-NET, immunophenotyping, copy-number alterations, exome sequencing, inhibitor screening, vorinostat, trametinib,