Abstract Library

#1707 Implication of Neuropilin-2 in the Progression of Small Intestinal Neuroendocrine Tumors: Towards a Promising Therapeutic Target?

Introduction: Small intestinal neuroendocrine tumors (siNETs) are rare tumors that raise several clinical and therapeutic challenges. Current treatments are not efficient, in part because of a poor understanding of their mechanisms of progression. We recently highlighted some axon guidance molecules (AGMs) that might be implicated in the progression of siNETs. Among them, we are currently focusing our efforts on the semaphorin 3F receptor neuropilin-2 (NRP2).

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Bollard J, Massoma P, Patte C, Carbonnaux M, Vercherat C,

Keywords: siNETs, progression, NRP2 ,

#1539 Slit-Robo Signaling Links to Ras Activity to Suppress Metastasis and Is Associated with Time-to-Progression in Pancreatic Neuroendocrine Tumors

Introduction: mRNA signatures of distinct metastatic phenotypes of pancreatic NETs (pNETs) exhibit differences in several components of the Slit-Robo axon guidance system.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Fischer C

Authors: Detjen K, Göhrig A, Hilfenhaus G, Körner J, Lombardi M,

Keywords: Slit2, Robo1, pancreatic, NET, pNET, metastasis, mouse model,

#770 The Axon Guidance Molecules Slit2 and Robo Control Motility and Growth of Pancreatic Neuroendocrine Tumor Cells

Introduction: Dense vascularization and high frequency of metastasis in pancreatic neuroendocrine tumors (pNET) suggest a central role for the interaction of tumor cells and vessels. Slit2 and its receptors Robo1 and Robo4 act as guidance cues in neurogenesis, angiogenesis and epithelial morphogenesis, and hence represent attractive candidate regulators at the tumor cell/stroma interface.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Fischer C

Authors: Detjen K, Hilfenhaus G, Göhrig A, Körner J, Welzel M,

Keywords: Axon guidance, Slit2, Robo, NET, metastases, motility,

#604 Expression of Netrin-1 and its Receptors in pNETs

Introduction: Netrin-1, a member of axon guidance molecules, and its dependence receptors (DCC, UNC5, neogenin) is involved in several cancer types (breast, neuroblastoma, colon etc) but its role in pNETs remains unknown.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Benslama N, Bollard J, Massoma P, Vercherat C, Hervieu V,

Keywords: netrin-1, pNET, progression,

#603 Role of Semaphorins and Their Signaling Pathway in the Progression of Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs)

Introduction: Semaphorin family, a part of axon guidance molecules, is involved in many types of epithelial cancers. However, little is known about its potential function in GEP-NETs.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Bollard J, Massoma P, Blanc M, Vercherat C, Lepinasse F,

Keywords: semaphorins, progression, biomarker,